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Advantages of Fluid Bed Dryer in Pharmaceutical Industry -
THE BOMBAY ENGINEERING WORKS

Fluid bed dryer plays an integral role in the pharmaceutical industry. This is due to the many advantages that it offers over the conventional drying techniques.

So far, a number fluidized bed drying studies have established that it is the most reliable and dependable technique in the pharmaceutical industry.

With this information, you can comfortably choose the right pharmaceutical fluid bed dryer.

Advantages of Fluid Bed Dryer :
The available fluidized bed dryers offer a wide range of benefits depending on their unique design.

Below are the main advantages of fluidized bed dryers in the pharmaceutical industry :
1. Fluidized Bed Dryers Guarantee Fast and Homogeneous Drying
• The hot gas/air flows into the system with a velocity greater than the setting velocity of particles. This causes the particles to be suspended in the hot air or gas.
• In this fluidized state, the particle you intend to dry is actually in direct contact with the hot gas or air. Therefore, drying can be done within 10 to 40 minutes.
• Furthermore, the uniform drying is due to the fact that every particle of the solid is surrounded by hot air or gas.
• Whether you opt for a vertical or horizontal fluidized dryer, the working principle will still remain the same.

2. Fluid Bed Dryer is Suitable for Heat Sensitive Products
• Some powders and granules degrade or lose essential properties when subjected to extreme heat or temperatures.
• This makes the conventional drying systems unsuitable for such products.
• The modern fluidized bed designs have sensitive and effective sensors that monitor all essential parameters during material drying process.
• Even with the high rate of mass and heat transfer, you can still control the basic parameters that affect quality of the final product.
Fluid Bed Dryer Control Panel :
• With this control panel, you can easily monitor the temperature and air flow settings.
• That is, with the modern control system, you can adjust all parameters of the inlet air flow.

3. Fluidized Bed Ensures Efficiency in Material Drying
• The fluid bed dryer working principle is such that the particles are dried individually as opposed to the entire bed. Remember, the hot air or gas surrounds all particles and this ensures efficiency in the material drying process.
• Hot air or gas reaches every surface of the particles
• This guarantees 99.9% efficiency in the drying process while saving thermal heat.
• Normally, you’ll find that the thermal efficiency of fluid dryers is 3 times greater than those of other conventional drying systems.

4. Handling Fluidized Bed Dryer is Easy and Less Labor Intensive
• A number of fluid bed dryer designs are such that you can conveniently relocate them from one point to another. This makes handling these machines easy and less labor intensive.
• Furthermore, there are those that have wheels, making them portable material processing equipment.
A Fluid Bed Dryer with Wheels :
• This makes fluid bed dryer a perfect choice for most laboratory and R & D applications.

5. Fluid Bed Dryer Designs Come in a Wide Range of Capacities and Sizes
• Whether you’re in pharmaceutical, laboratory or R&D facility; there is that fluidized dryer design that will suit your unique application requirements. For instance, we have a wide range of fluid bed dryer equipment optimized for different applications.

6. Fluid Bed Dryer has Low Maintenance Cost hence, Reduces Downtime
• This is quite clear from the modular and cGMP compliant designs of our fluid bed dryers for pharmaceutical machines. The equipment is made from high quality stainless steel.
• Ideally, you don’t have to worry about product contamination, dust pollution, rust or tedious cleaning process.
• Furthermore, with the modular design, you can easily replace or modify this machine to suit your unique applications.
• NOTE: In case you have to modify our machines, kindly contact our technical team. Remember, hiring untrained personnel will make your warranty invalid.

7. No Hot Spots on the Final Products
• The hot spot is a common phenomenon in most drying equipment. This is because the products are in direct contact with the drying surface.
Fluid Bed Material Processing Chamber :
• All materials are suspended within the material drying chamber.
• Additionally, you can choose the right capacity of the fluid dryer where there is an excellent mixing of both the particles and air.
• Remember, in other drying applications, you cannot use high temperatures since this may cause damage to the product.
• However, for the case of fluid bed dryer, you can use high drying temperature.
• Again, due to the unique fluid bed dryer working principle; you can use this machine to dry thermolabile products. This is one of the main reasons why fluidization is common in most pharmaceutical industries.

8. Fluid Bed Dryer Is Suitable for both Continuous & Batch Material Processing
• Do you need a drying machine for both batch and continuous material processing?
• Well, I can recommend a fluidized bed dryer since it is a machine that can handle both processes without necessarily doing expensive adjustments or modifications.
Apart from these 8 advantages of fluid bed dryer, other includes :
• No risk of soluble substances migrating
• Reduced dust pollution
• Small size with high production capacity
• High rates of moisture removal
Even though a fluidized bed dryer may offer all these advantages; it may not be suitable for all pharmaceutical applications. It is for this reason that we may advise you to consider other alternatives.

Besides, even when you adopt fluid bed dryer, there are certain challenges that you’ll have to deal with.

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“Contra Rotating Mixers : THE BOMBAY ENGINEERING WORKS”

Contra rotating mixers are typically used when thick emulsions are produced by a bottom entry emulsifier or homogenizer. They are also very useful for multi task vessels where different process duties are required.

Advantages :
Contra rotating mixers have the advantage of utilizing the benefits of a turbine unit with the benefits of an anchor / scraper. Contra rotating mixers offer excellent mixing throughout the vessel as viscosities increase due to their double mix system. A contra rotating mixer is fitted with two drives; an anchor / scraper drive and a centrally mounted turbine drive. In effect it is two mixers joined together. The wet end can be complete and installed into the tank prior to the vessel being completed or can be fully split to allow simple installation / removal.

Areas of Applications :
The mixer is highly versatile and mostly used for manufacturing Tooth Paste, Creams, Cosmetics and other viscous products.

Operation Principles :
Contra Mixer as the name suggests works on the principle of Contra rotation of Blades for simultaneous beating and scraping operation. The Mixing Assembly consists of series of paddle type blades of appropriate shape to move the material back towards the centre of the container.

The paddle type blades are provided on the central shaft which runs through a hollow shaft on which other sets of blades are welded. Both the sets of blades intermeshes with each other and rotates in clockwise and anti-clockwise direction respectively and one sets also scraps the container wall for thorough and uniform mixing of the material.

The mixer is so designed to withstand high vacuum applied during the process for optimum mixing. Contra Mixer is provided with a jacket for cooling or heating as per the application. The vessel shall have a shell of suitable thickness with a hemispherical bottom and flanged top dish made out of SS 316 plate.

The vessel shall be jacketed with MS jacket (SS 304 jacket provided on extra cost on demand, if required) of suitable with stiffeners suitable for steam pressure of 4 to 5 Kg/cm2. The jacket shall be insulated with 50 mm thick glass wool insulation and shall be cladded with 16 SWG M.S. or SS 304 materials. The vessel shall be suitable for 600 to 700 mm of Hg vacuum and internal pressure of 3 Kgs / cm2.

Salient Features :
• All contact parts AISI 304 or 316,304L or 316L.
• Jacketed mixers are provided for heating of products during mixing.
• Provision to mix / blend the viscous products under vacuum for de-aeration purpose.
• High shearing action because of contra rotary motion & homogenizer.
• Mechanical seal is provided instead of stuffing box for main shaft sealing for vacuum operation.
• Anchor blade assembly with adjustable Teflon scrappers is provided to avoid localized heating & ensure uniform mixing.
• Top drive & agitator assembly can be lifted & lowered by motorized as well as hydraulic operations if required.
• Smaller version of Contra Rotary Mixers is provided with lifting arrangement for the bowl instead of top drive & agitator assembly.
• Pneumatic system is also available for lifting & lowering top drive & agitator assembly for smaller version of Contra Mixer.
• Available in Standard Model and GMP Models.
• Capacity Available : 50 to 10,000 Ltrs.

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“Current and Future Direction of Packaging in Pharmaceutical Industry : The Bombay Engineering Works”

Continuous innovation in manufacturing and packaging has led to rapid development of new products and technologies aimed at increasing and enhancing efficiency. There has been constant innovations in pharmaceutical packaging such as blow fill seals, plasma impulse chemical vapour disposition (PICVD) coating, snap off ampoules, unit dose vials, two in one prefilled vial design, ready filled syringes and child proofing.

Areas of Innovation :
Safety, threat of contamination and counterfeit prevention, cold chain compliant packaging, patient compliant, and regulatory factors have been areas that have driven improvement in innovations of packing.

Administration Methods :
The traditional administration methods have been -
• Oral tablets and capsules packed in forms of blister packs or in plastic bottles
• Powders , pastilles and liquids are also orally taken

New administration methods have emerged such as intravenous administration, Inhalation and transdermal methods. These new techniques have necessitated newer packaging methods to be developed for these techniques.

Liquid Filling Machines :
The need to develop products that can address various market requirements has been an area of focus among many manufacturers. New products such as nutritionals require varying dosages in packaging and equipment must have the ability to deliver these quantities. These functional expectations of the manufacturers including logistical processes, easy pouring, and handling have continued to drive new trends. Some important developments include liquid filling machines for both bottles and poaches, nonstop film change, pouch dispensers and poach cutting machines.

Vial Filling Machines :
Focus has been improving flexibility, reliability and efficiency, reducing risk of contamination and eliminating personnel exposure to potent chemicals. Lengthy transfer piping (requiring cleaning and validation) are being replaced by simple mounting of pre sterilized tubing sets. Vial filling Machines carriers are also designed for wider range of bottle diameters, which reduces cost of spare parts, reduces changeover time.

Liquid Bottle Filling Machines :
Currently, there has been the development of two in one vial multi chamber dispensers, which involves packaging of the main product followed by a separate packing line for dilution water, meant to mix with product during product usage.

There has also been advancement in machine controls through use of programmable logic controls, and inclusion of safety devices. Inclusion of automatic hopper level control provides faster change over time.

Volumetric Liquid Filling Machine :
While these equipments can pack a wide range of viscosities and temperatures, usage with shear sensitive fluids may pose certain challenges , most common being particles getting trapped between the piston and the cylinder. These have been substituted with diaphragm pumps as well as peristaltic pumping systems

Rotary Filling Machine :
There have also been improvements in levels of automation with rotary filling machines modified to be able to pack paste products as well as granulated and powdered products.

Conclusion :
With a rapid increase in self-administered medications, most delivered through injections, there has been a growing need for patient friendly packaging systems that must ensure safety during transport, tamper evident, and difficult to counterfeit. Equipment manufacturers have also responded with advanced systems that comply with dosing accuracy, safe and efficient in handling.

The market also requires accurate traceability systems that can help track the product throughout the supply chain.

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“ZERO HOLD UP SPARKLER FILTER PRESS MANUFACTURERS IN INDIA – THE BOMBAY ENGINEERING WORKS”

We are leading at Zero Hold Up Sparkler Filter Press manufacturers in India. With experience and knowledge, we have built broad client base across worldwide. This Zero Hold Up Sparkler Filter Press machine is manufactured by us with very high quality material and as per the international industry standards to meet the changing needs.

Zero Hold Up Sparkler Filter Press manufacturers in India has been tested at various levels and it requires very low maintenance. The Zero Hold Up Sparkler Filter Press manufacturers in India consists of an assembly of filter plates and filter cloth with perforated S.S. supporting screens enclosed in an S.S. shell. The assembly is equipped with a pump to pressurize the liquid through the stack of horizontally arranged filter plates. With the help of our professionals, we are able to put forth widely appreciated zero hold sparkler filter press at pocket friendly prices.

Owing to our expertise in this domain, we are involved in offering a broad range of Zero Holdup Filter Press to our clients spanning Worldwide.

APPLICATION :
To filter final product in Pharmaceuticals, Perfumes, I. V. Fluids, Dyes & Chemicals, Activated carbon, Pesticides, Cosmetics, Varnishes, Polymers, Resins & Paints, Sugar syrup, Food, Plant Water Polishing, Fruit juice, Soft drink, Beer & Liquors, Edible & Non Edible oils.

SIZE AVAILABLE :
8” / 14” / 18” / 24” & 33” dia.
OPERATION :
• The liquid to be filtered is forced in the chamber by the Transfer pump, where it finds its way to the top of the filter media of each plate through circular opening on the side of the plates.
• Under pressure clear Liquid passes through the filter media leaving suspended particles on top of the filter.
• The clear filtrate runs down through central channel formed by the interlocking cups and exists through the outlet valve.

FEATURES :
• Single pass clear filtration.
• Full batch recovery of the filtrate.
• Easy install inside cartridge assembly.
• Complete cake retains on the plate.
• Uniform distribution of cake on each plate.
• Reduce the cost of treatment of catalyst, Toxic Chemicals.
• Less exposure to the operating person.
• No contamination of the internal surface of the shell.

ADVANTAGES :
• Zero retention in filter vessel.

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Automatic Linear Tube Filling Machine is designed for tube filling, sealing & coding process in high speed to be completely untouched with single machine process. Tubes are loaded in bulk the process is fully automatic for filling, sealing & coding This unit comes in various batch capabilities to handle a large range of tube sizes and shape by change parts as per requirement further the maximum production capacity 80 to 120 tubes per minute can easily be obtained by this machine.

Application in hair dye tube filling machine, chemical tube filling machine, sauce tube filling machine, glue tube filling machine, cosmetic tube filling machine, wax tube filling machine, shaving cream tube filling machine, gel tube filling machine, pesticide tube filling machine.

Product Detail :
• Machine Capacity fills from 5 gram. to 250 gram. Max output: 40/60/80/100/120 tubes per min.
• Machine body Construction Stainless Steel high quality on heavy duty fabricated, with Epoxy Powder Coated structure with all Safety Cover made from SS 304 and all contact parts with SS 316 grade.
• Filling System -Positive Suction & Displacement. Attached with Pneumatic Blow Tail Cut-off with Control System.
• NO TUBE - NO FILL Device with Filling Accuracy +/ - 0.1%..
• Indexing System Geneva Mechanism.
• Syringe Pump Single Head Type Insert for Filling (5 Grams. to 30 Grams.) (30 Grams. to 100 Grams.) (100 Grams. to 250 Grams.) Any one of the three sets will be provided against requested specification in your order.
• Jacketed Hopper Double Head Type of Capacity of 40 liters. Temperature Controller with SS Tubular Heater. Belt Less Stirrer Device with augur to keep the product in Continuous homogeneous condition. Geared Motor 0.5 HP, RPM-40. With Label Sensor and controller.
• Lami / plastic Tube heating device Activate on Leicester with Hot air Tool adopter Jacketed SS-304, one set. And tube-heating adopter cooling ring centres the tube so That heating is uniform around the tube. Blower: 0.5 HP. one set.
• Lami / plastic Tube Sealing Device Activate on Pneumatics. In sealing & coding wherein the tube is pressed & sealed and then coded with metal stereos coding letter punch (female 0 to 9, one set).
• Electronic Digital filled Tube Production Counter.
• Overload Clutch for Centering and Micro Switch Cut-Off System.
• Main Motor 2 Hp, With Separate Drive System.

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Automatic Container Filling Machine (for creams and ointments)

High speed automatic multi head container filling machine for filling cream, paste, ointment, wax polish, grease, jam, sauce etc. in plastic or tin containers or jars, bottles etc.
Containers like flat tins or bottles are loaded on turntable from where they are transferred onto a conveyor belt. They are then indexed into the filling station.

No-Container-No-Fill device will stop dozing operation if containers are not in place. SS jacketed hopper with 2 KW heater and stirrer can be provided as an option to facilitate easy filling of highly viscous products. Filled containers are transported over conveyor for further operations and handling.

Features :
• PLC Controlled machine with colour Touch Screen
• Can fill creams of various viscosity
• No –Container – No – Fill interlock
• Tail Cutting arrangement after dozing
• Easy change over from one size to another
• Fill quantity can be accurately adjusted
• Fill accuracy up to ±0.5%
• Simple in operation and maintenance
• Jacketed hopper with stirrer for high viscosity products can be provided as an option

* Fill Range with interchangeable Filling Syringe of different capacity
# Output depends on fill quantity and material characteristics.

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“What Can Ribbon Mixers Do For You? – THE BOMBAY ENGINEERING WORKS”

With benefits ranging from ease of cleaning to low energy use, ribbon mixers are an efficient solution for food manufacturers working with powder materials and ingredients.

When it comes to working with free-flowing or sticky powder material, ribbon mixers are a very popular solution throughout the food industry. With a simple structure, ease of cleaning, and low energy use, ribbon mixers are used by heavyweight food manufacturers like Kraft, General Mills, Pepsi, Mars, and many others. Here are some of the benefits and advantages, in greater detail, of ribbon mixers.

Straightforward Design :
Ribbon mixers employ a simplistic design and structure with a limited number of components. The mixer consists of a ribbon agitator, U-shaped vessel, two end plates, and a drive unit. Thanks to its straightforward design, the ribbon shaft can be easily cleaned and troubleshooting and maintenance are conveniently performed. Additionally, the smooth surface and rounded edges ensure any leftover residues can be easily removed.

Drive Unit :
Since the ribbon mixer is only a mild mixing machine, the shaft speed does not need to be fast and therefore does not require a high-powered motor for the drive unit. Additionally, just like the mixer’s overall structure, the structure of the drive unit is very simple and can be separated into a belt drive and direct connection drive. Another added benefit is that there is no risk of oil pollution into the product since the drive unit is located outside and away from the mixing vessel.

Seal Construction :
Food manufacturers prefer simple and effective seal structures that can be easily maintained and changed in the future. With this in mind, the ribbon mixer uses a split packing seal structure that allows for the quick and easy alteration of the packing seal, making the mixer adaptable to a variety of processes.

Discharge :
To reduce residue and limit the amount of wasted space, flap valves are the best choice for discharge. Slide gate valves and butterfly valves are effective options as well, but with roughly 80mm of height space, the flap valve tends to provide the most efficient spatial use, as the valve can lie flush with the bottom of the vessel.

Easy To Clean :
As mentioned earlier, the mixer is designed to be easily cleaned and maintained. The lid on the top of the ribbon mixer allows a worker to easily clean the machine from the top. Additionally, a safety grid and safety switch ensures that there is no potential for injuries to occur during cleaning.

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Advantages of Fluid Bed Dryer in Pharmaceutical Industry - THE BOMBAY ENGINEERING WORKS

Fluid bed dryer plays an integral role in the pharmaceutical industry. This is due to the many advantages that it offers over the conventional drying techniques.

So far, a number fluidized bed drying studies have established that it is the most reliable and dependable technique in the pharmaceutical industry.

With this information, you can comfortably choose the right pharmaceutical fluid bed dryer.

Advantages of Fluid Bed Dryer :
The available fluidized bed dryers offer a wide range of benefits depending on their unique design.

Below are the main advantages of fluidized bed dryers in the pharmaceutical industry :

1. Fluidized Bed Dryers Guarantee Fast and Homogeneous Drying
• The hot gas/air flows into the system with a velocity greater than the setting velocity of particles. This causes the particles to be suspended in the hot air or gas.
• In this fluidized state, the particle you intend to dry is actually in direct contact with the hot gas or air. Therefore, drying can be done within 10 to 40 minutes.
• Furthermore, the uniform drying is due to the fact that every particle of the solid is surrounded by hot air or gas.
• Whether you opt for a vertical or horizontal fluidized dryer, the working principle will still remain the same.

2. Fluid Bed Dryer is Suitable for Heat Sensitive Products
• Some powders and granules degrade or lose essential properties when subjected to extreme heat or temperatures.
• This makes the conventional drying systems unsuitable for such products.
• The modern fluidized bed designs have sensitive and effective sensors that monitor all essential parameters during material drying process.
• Even with the high rate of mass and heat transfer, you can still control the basic parameters that affect quality of the final product.
Fluid Bed Dryer Control Panel :
• With this control panel, you can easily monitor the temperature and air flow settings.
• That is, with the modern control system, you can adjust all parameters of the inlet air flow.

3. Fluidized Bed Ensures Efficiency in Material Drying
• The fluid bed dryer working principle is such that the particles are dried individually as opposed to the entire bed. Remember, the hot air or gas surrounds all particles and this ensures efficiency in the material drying process.
• Hot air or gas reaches every surface of the particles
• This guarantees 99.9% efficiency in the drying process while saving thermal heat.
• Normally, you’ll find that the thermal efficiency of fluid dryers is 3 times greater than those of other conventional drying systems.

4. Handling Fluidized Bed Dryer is Easy and Less Labor Intensive
• A number of fluid bed dryer designs are such that you can conveniently relocate them from one point to another. This makes handling these machines easy and less labor intensive.
• Furthermore, there are those that have wheels, making them portable material processing equipment.
A Fluid Bed Dryer with Wheels :
• This makes fluid bed dryer a perfect choice for most laboratory and R & D applications.

5. Fluid Bed Dryer Designs Come in a Wide Range of Capacities and Sizes
• Whether you’re in pharmaceutical, laboratory or R&D facility; there is that fluidized dryer design that will suit your unique application requirements. For instance, we have a wide range of fluid bed dryer equipment optimized for different applications.

6. Fluid Bed Dryer has Low Maintenance Cost hence, Reduces Downtime
• This is quite clear from the modular and cGMP compliant designs of our fluid bed dryers for pharmaceutical machines. The equipment is made from high quality stainless steel.
• Ideally, you don’t have to worry about product contamination, dust pollution, rust or tedious cleaning process.
• Furthermore, with the modular design, you can easily replace or modify this machine to suit your unique applications.
• NOTE: In case you have to modify our machines, kindly contact our technical team. Remember, hiring untrained personnel will make your warranty invalid.

7. No Hot Spots on the Final Products
• The hot spot is a common phenomenon in most drying equipment. This is because the products are in direct contact with the drying surface.
Fluid Bed Material Processing Chamber :
• All materials are suspended within the material drying chamber.
• Additionally, you can choose the right capacity of the fluid dryer where there is an excellent mixing of both the particles and air.
• Remember, in other drying applications, you cannot use high temperatures since this may cause damage to the product.
• However, for the case of fluid bed dryer, you can use high drying temperature.
• Again, due to the unique fluid bed dryer working principle; you can use this machine to dry thermolabile products. This is one of the main reasons why fluidization is common in most pharmaceutical industries.

8. Fluid Bed Dryer Is Suitable for both Continuous & Batch Material Processing
• Do you need a drying machine for both batch and continuous material processing?
• Well, I can recommend a fluidized bed dryer since it is a machine that can handle both processes without necessarily doing expensive adjustments or modifications.

Apart from these 8 advantages of fluid bed dryer, other includes :
• No risk of soluble substances migrating
• Reduced dust pollution
• Small size with high production capacity
• High rates of moisture removal
Even though a fluidized bed dryer may offer all these advantages; it may not be suitable for all pharmaceutical applications. It is for this reason that we may advise you to consider other alternatives.

Besides, even when you adopt fluid bed dryer, there are certain challenges that you’ll have to deal with.

============================================
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============================================
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LIQUID SYRUP MANUFACTURING PLANT

LIQUID SYRUP MANUFACTURING PROCESS :

APPLICATION & PROCESS :
The Bombay Engineering Works has been designed & manufacturing preparation vessels and has consolidated a process knowledge concerning sterile injectable solution, dispersions, ophthalmic products, syrup and suppositories.

OPERATION :
The feed container moving on conveyor belt are fed into star wheel, bringing the container below the sealing head in the subsequent indexing part, meanwhile the bottle pick up a cap from the delivery chute of cap feeding bowl, where the body and the neck of the container are positioned below the rotating head. Where the sealing head is performing perfect operation of threading & sealing.

PREPARATION VESSELS & TANK :
• Extremely hygienic processing.
• Least manual handling.
• Design compliance with cGMP
• Capacity up to 5,000 Liters.
• Product Contact AISI 316L
• Atmospheric, Vacuum or Pressure Operation.
• Jacket for heating & cooling.
• Vessel Inside Pressure (-1 /+3 Bar)
• Heating Jacket Pressure (-1 /+6 bar)
• Heating by steam or hot water circulation.
• Thermal Insulated.
• Mechanicals or Electro polishing of internal surface.
• Welded, flanged or hinged type cover
• Integrated Cleaning in Place-CIP.
• Sterilizing In Place-SIP as an Option.
• Portable execution on request.
• Validation protocols & Instrumentation celebration.

VARIABLE SPEED AGITATION :
• Agitator can be top or bottom driven or magnetically driven.
• Propeller type, Anchor type provided with High speed disperser or rotor-stator homogenizer.
• Single or double mechanical seal.

FULLY AUTOMATIC LIQUID SYRUP MANUFACTURING PLANT CONSISTING OF :
• Sugar Charging / Transfer System.
• Sugar Melting Vessel with mixing stirrer.
• Basket Filter & Transfer Pump.
• Syrup Manufacturing Vessel with stirrer.
• Inline Homogenizer.
• Zero Hold up Filter press.
• Storage Tank with stirrer.
• Interconnecting pipeline.
• Transfer Pumps.
• Integrated automatic control panel.
• Working Platform.

TURN KEY PROCESS LINE :
• For production, filtration, transfer and storage solution.
• Pre reparation vessels.
• Inline homogenizer.
• Inter Connecting Pipe
• Solid or sugar Charging System
• Working Platform.

UNIQUE FEATURES OF THE FACILITY :
• The liquid oral manufacturing plant is designed to be operated by one operator and one helper, saving on precious man-power costs.
• Sugar syrup and manufacturing vessels are provided with limpet coils for heating and cooling, designed for internal vacuum to facilitate transfer of sugar directly from stores to sugar syrup vessel.
• Sugar syrup is transferred to manufacturing vessel through online sugar syrup prefilter by vacuum.
• Entries of all propeller agitators are from bottom through a specially designed cartridge mechanical seal with TC/TC seal face.
• The advantage of the bottom propeller agitator over the conventional agitator is that there are no vibrations of shaft, no couplings in the drive assembly, leading to lower maintenance cost for liquid oral manufacturing plant.
• Pipes, pipe fittings and valves are of SS 316, seamless, internally electro polished with DIN standard unions and silicon Gaskets.
• Manholes of all the vessels are equipped with davit fitting and the cover of the manhole slides instead of being lifted.

AUTOMATION AVAILABLE, APPROPRIATE FOR THE INTENDED PROCESS FUNCTION, INCLUDING CIP AND SIP :
• Controls of all function by PLC Controls with HMI Touch screen.
• Level controls by means of capacitance probe or electronic load cells.
• Digital indication and controls of all process parameters for Process time, agitator speed, temperature, pressure & level.

CAPACITIES AVAILABLE : 50 Ltrs to 15000 Ltrs

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"THE ADVANTAGES OF V BLENDERS : THE BOMBAY ENGINEERING WORKS"

Today, a variety of different types of blenders and mixers are available on the market for industrial and commercial use. As a result, it is important to ensure the selection of the right equipment for the application and industry in which it will be used.

Among the most popular types of blenders available for the pharmaceutical, chemical, food and beverage industries is the V blender. In deciding whether V blenders are the right choice, it is important to consider the advantages and disadvantages offered, as well as learn more about the most suitable applications for this type of equipment.

V blenders offer a number of advantages, including the fact that this type of blender can minimize particle size reduction due to the lack of any moving blades. As a result, V blenders are suitable for use with fragile materials. Additionally, this type of blender works to eliminate product contamination. The shape and design of the V blender also makes it quite easy to clean.

While V blenders do offer many advantages, there are some potential drawbacks, including the fact they are not typically suitable for mixing particles of different densities and sizes that could segregate when they are discharged.

V blenders are typically used in the dry blending of solids that are capable of free flowing. This is why this blender is often used in the pharmaceutical industry.

Additionally, V blenders may also be used with the following :
• Dry flavours
• Milk powders
• Food products
• Ceramics powders
• Coffee
• Animal feeds
• Pigments
• Herbicides and pesticides
• Fertilizers
• Spice blends
• Cosmetics
• Baby foods

Given their versatility and many advantages, V blenders can be an excellent addition to many industries. Developing a greater understanding of the most applicable uses for a V blender can help you to make a more informed decision.

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“Ointment Manufacturing Plant : The Bombay Engineering Works”

Ointment Manufacturing Plant is an ideal tool for the pharmaceutical & cosmetic industries for the production of Ointment, Cream, Lotions, Tooth Paste & other emulsions & homogenizations.

It is specially designed to take care of two critical factors which directly affect the quality of the Ointment/Creams.
• Minimum man handling of Ointment.
• Negligible vacuum drop during mixing & blending.
• Needless to say, it also provides the benefits of the effective manpower utilization.

Features of Ointment Manufacturing Plant :
• Easily cleanable and completely untouched process, less chance of contamination.
• All contact parts made of Stainless Steel 316 and non- hence contact part ss 304 material.
• All pipelines are electro polished from inside and joints are easy openable.
• Complete cover lifting arrangement to facilitate cleaning at the time of product change over.
• Especially semi-contra & Double contra designed anchor stirrer with flexible Teflon scrapers.
• The plant is provided with pre-mixing wax and water phase vessels and the main manufacturing vessel.
• The main vessel is provided with a slow speed anchor agitator for mixing and a bottom high speed homogenizer for emulsifying.
• Variable speed drive provided for main anchor stirrer assembly for different speeds.
• Jacketed vessels for heating/cooling processes.
• Inspection glass with illumination.
• Specially designed inline filters can also be provided to ensure proper filtration.

Optional Requirement are :
1) Load cell for accurate weighing.
2) PLC based control panel for process automation.
3) Contra type agitator for calcium base toothpaste.
• The Ointment Manufacturing Plant / Cream Manufacturing Machine is suitable for manufacturing pharmaceutical ointments, sterile preparations, cosmetic creams, suspensions, gels, etc.

Equipments of Ointment Manufacturing Plant :
• Wax heating Vessel.
• Water Melting Vessel.
• Manufacturing vessel.
• Storage vessel.
• Interconnecting pipeline.
• Pumps -Lobe Pump and metering pumps.
• Integrated automatic control panel.
• Working Platform.
• Process Description of Ointment Manufacturing Plant :
• All vessels are manufactured from S.S. 316 grade stainless steel sheets and are cGMP compliant construction.
• The vessels are Jacketed, insulated, cladded and with suitable agitator assembly in each vessel.
• Wax is melted in Wax melting vessel; Water is heated in water heating vessel.
• Both wax and water are transferred into the manufacturing vessel automatically through vacuum.
• In manufacturing vessel both wax and water are homogenized to make a uniform emulsion and cooled by passing chilled water into the jacket of manufacturing vessel.
• After the emulsion is formed active ingredients/colors etc. are added and are thoroughly mixed and homogenized.
• The same is transferred by bump pump into the storage vessel. From the storage vessel it is automatically transferred into the filling machine by means of metering pump.
• Flow rate of metering pump can be set as per your tube filling machines speed and capacity.

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Established in the year 1964, The Bombay Engineering Works have carved a niche as a prime manufacturer, supplier and exporter of Pharmaceutical, Chemical, Food, Cosmetic, Ayurvedic and Herbal Machineries.

We have been dealing in wide range of Pharmaceutical, Chemical, Food, Cosmetic, Ayurvedic and Herbal Machineries that is an ideal amalgamation of utility and quality. We work towards the vision of persevering to incorporate modern innovations set by prevalent international standards in every The Bombay Engineering Works product according to customer requirements.

We have adopted stringent quality measures that are practiced from the initial stage of production and continue till the final packaging of our products. We give prime importance to trust transparency and maintenance of cordial relations with our clients and thus have been able to maintain a satisfied list of customers.

We have a well-equipped infrastructural base equipped with advanced and latest technology machinery and equipment. All the machines and tools are managed by a team of experienced and skilled experts, which works in close coordination with each other for offering what a client looks for. Starting from the procurement of raw materials to the delivery of end products, all the production stages are inspected by experts. With huge warehousing facility and fully fledged packaging unit, we have been meeting bulk demands of the clients on time.

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“Multicolumn Distillation Plant : The Bombay Engineering Works”

To industries where 100% pure Pyrogen - free water-for injection plays role, Multicolumn Distillation Plant is the perfect Multicolumn Distillation Plant solution. Available in capacities ranging from 80 - 5000 LPH, the Multicolumn Distillation Plant is used for its economy, low maintenance and low operation costs.

Some of the special features of Multicolumn Distillation Plant are:
• Pure Sterile Pyrogen free distilled water conforming to USP standards.
• Compact in design.
• All contact Parts are in SS 316 / SS 316 L.
• Electro polished crevice less inner contact surfaces.
• PLC based system for automated operation.
• Sanitary triclover fittings for quick and easy preventive maintenance.
• Double tube Sheet construction for the first column, where boiler steam is present.
• Synoptic panel board with facility for logging the data can also be given.

Multi Column Distillation Plant :
We offer a range of multi column distillation plants that are manufactured from high-grade raw material and have a capacity of 50 to 2500 ltrs.

APPLICATION :
To generate WFI water for injection / large volume of Parenteral.
CAPACITY : 50 to 2500 Ltrs.

TECHNICAL SPECIFICATION :
Distillate:
• IP/BP/USP specifications compliance.
• Distillate Temperature 95ºC
• Conductivity: Less than 0.5µ Siemens/cm.
• Endotoxin – Less than 0.25 Eu./ml.
• TOC – 100 PPB.

FEED WATER :
• Purified water with max. Conductivity of 0.5 microchips/cm. should be used.
• Pressure should be 1 kg/cm² higher than the in feed steam pressure.
• Temperature – Ambient 30ºC

COOLING WATER :
• Normal tap water is used
• Provided hardness is less than 90 PPM of CaCo3.
• Temperature – Ambient 30ºC

STEAM :
• Steam must be saturated, dry free from oil, vapours and other impurities.
(A steam filter to obtain 3µ, clear quality steam is recommended ask for details)
• Pressure –min steam pressure of 3 kg./cm² is essential to guarantee pyrogen-free distillate.

OPERATION :
• To feed purified water & heat with boiler steam & generate clean steam and condense with cool water which is WFI.

FEATURES :
• Energy Saving - Low operating cost.
• Compact Design - Space saving.
• All contact parts are SS 316L and all joints are sealed with Teflon Gasket.
• Fully Automatic operation - No Attendant required.

ADVANTAGES :
• Save water consumption & Boiler steam consumption.
• Complete close loop system. No air contamination.
• On line conductivity.
• If substandard conductivity will come dumping automatically through 3 way valve.

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The vacuum tray dryer is equipment used in the drying of the heat sensitive and hygroscopic materials.

DESCRIPTION :
Vacuum dryer is a modified form of the vacuum still. The vacuum dryer which is in common use in the pharmaceutical industry is called vacuum oven. It consists of a jacketed vessel made of materials which can withstand vacuum with in the oven and steam pressure in the jacket.

The oven can be closed by a door that can be lacked tightly to provide an air tight seal. The oven is connected to a vacuum pump through a condenser and a receiver. At the pressure of about 0.03 to 0.06 bars vacuum oven is operated generally.
At this pressure water boils at 25 -35 degree centigrade. In the pharmaceutical industry an oven of the size of about 1.5 m cubes having 20 shelves are commonly used.

Now days the vacuum ovens with a number of small compartments with small doors are available rather than one big compartments with a heavy door.

PRINCIPLE :
In vacuum dryer materials is dried by the principle or applications of vacuum. The water boils at a lower temperature when the pressure is lowered by creating the vacuum. So evaporation of water takes place faster.

CONSTRUCTION :
The construction of the vacuum dryer is made of with stand high vacuum pressure with cast iron heavy jacketed vessel which with stand the steam pressure in the jacket. It has enclosed space and divided in to 20 hollows shelves portions which are part of the jacket.

These shelves provide conduction of heat due to larger surface area about 45 to 50 m square provided by shelves and metal trays are placed over the shelves for keeping the materials. The oven door is locked tightly to give an air tight seal and is connected to a vacuum pump by placing condenser.

WORKING :
• The trays which are present in the dryer are used to dry the materials which are placed on the shelves and the pressure is decreased up to 30 to 60 kps by vacuum pump.
• Door is closed firmly and steam is passed through the space of jacket and shelves. So that the heat transfer takes place by the mechanism of conduction.
• Be vacuum evaporation the water is taken out from the material at 25 - 30 @c.
• Water vapour passes in to the condenser and after drying vacuum line is disconnected then the materials are collected from the trays.

PHARMACEUTICAL APPLICATIONS :
• Vacuum dryer can be used for the drying of the following
• Heat sensitive materials, Dusty materials and hygroscopic materials, toxic materials can be dried in this vacuum dyer.
• Feed materials containing the solvents are also dried by this vacuum dryer. The solvent material can be recovered by the condensation process.
• Drugs which are required as porous end products.
• Friable dry extracts can be obtained through this drying process.

ADVANTAGES :
• Handling of the materials is easy in this drying because of tray arrangement inside the dryer.
• It is easy for switching over to the next materials.
• Hollow shelves which are electrically heated can be used.
• It provides large surface area. So the heat can be easily transfer throughout the body of the dryer and fast drying action takes place.
• Hot water can be supplied throughout the dryer which helps in drying process at the desired temperature.

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"Filling Technologies Used in Pharmaceutical Industries in Various Countries"

Most pharmaceutical products are packaged as either liquid or powders. Both of these products require advanced machines to handle their manufacturing and packaging.

Liquid filling machines -
There are a number of technologies that are used in different nations for filling liquid medicine. They range from small machines to more complicated systems.

Table top filling machines-
These were early machines used in packaging drugs and food. They ranged from manual, semi automatic and fully automatic systems. They use a pump to deliver the liquid to bottles. They are still in use in the developing nations, Africa, China and India. They are used by herbal medicine companies or those operating at a small scale.

They use electric pumps, peristaltic movement and pneumatic systems. Containers are handled by hand and this increases their susceptibility to biological and chemical contaminants.
Advanced liquid filling machines for vials and ampoules
Liquid filling machines are utilized by many pharmaceutical companies in the world.

They pass most drug agency regulation and codes since they achieve aseptic filling. These can be classified in terms of container type, speed, features, number of fill per operation and functionality.

The mechanism helps machine to fill vials or ampoules, an advanced method of cleaning, disinfecting, sealing and capping the containers.

Though different liquid filler employ a several filling techniques, the basic mechanism entails the use of piston, syringes and nozzles. The movement of piston sucks a metered quantity of the drug which is then delivered to the ampoules.

These machines are very popular in India, China, USA and Europe and are used by a vast number of pharmaceutical companies in packaging. Advanced sensors are used to monitor volume, container, speed, movement, sealing and other processes.

Liquid bottle / Monoblock filling machines-
These are advanced modern machines used to pack liquid chemicals into bottles. They are widely used in pharmaceuticals drug packaging for local and export market. They have advanced features for handling bottles, cleaning them, metering the fluid depending of density, viscosity and chemical properties, pouring the right quantity and filling.

The monoblock type is widely used as it is a complete set will advanced measuring and filling system, ROPP (roll-on-pilfer-proof) where a filled bottle is sealed with a screw able bottle cap inserted by rotating capping machines that descends on the bottle, screws the cap and also forms a tamper proof tuck broken during use.

Dry powder filling machines-
Dry powder filling machines are used as alternative to liquid methods. They are widely applied in packing powders that will be remixed in hospitals or by patients. The main machines applied include

Vacuum/ Injectable dry powders-
This is an advanced method of packing dry powder. The sterile powder is stored in a hopper that uses agitation to move and mix the material. Then powder wheel uses a vacuum to suck the required amount of materials from the hopper. A doctor wheel scoops excess material before it is delivered to the bottle. They have advanced features are widely used in economical packing in North America, China, India and Europe.

Auger type filling machines-
The auger type is more precise and has unbeatable accuracy in filling powders. It features a rotating auger that sucks a definitive amount of powder and transports it to bottles. This is followed by sealing and labeling.

Advanced specialized filling machine-
In addition, many export machines are customized to suit the user needs in terms of bottle size, capping and sealing method as well as other features.

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"LIQUID SYRUP MANUFACTURING PLANT"

LIQUID SYRUP MANUFACTURING PROCESS :

APPLICATION & PROCESS :
The Bombay Engineering Works has been designed & manufacturing preparation vessels and has consolidated a process knowledge concerning sterile injectable solution, dispersions, ophthalmic products, syrup and suppositories.

OPERATION :
The feed container moving on conveyor belt are fed into star wheel, bringing the container below the sealing head in the subsequent indexing part, meanwhile the bottle pick up a cap from the delivery chute of cap feeding bowl, where the body and the neck of the container are positioned below the rotating head. Where the sealing head is performing perfect operation of threading & sealing.

PREPARATION VESSELS & TANK :
• Extremely hygienic processing.
• Least manual handling.
• Design compliance with cGMP
• Capacity up to 5,000 Liters.
• Product Contact AISI 316L
• Atmospheric, Vacuum or Pressure Operation.
• Jacket for heating & cooling.
• Vessel Inside Pressure (-1 /+3 Bar)
• Heating Jacket Pressure (-1 /+6 bar)
• Heating by steam or hot water circulation.
• Thermal Insulated.
• Mechanicals or Electro polishing of internal surface.
• Welded, flanged or hinged type cover
• Integrated Cleaning in Place-CIP.
• Sterilizing In Place-SIP as an Option.
• Portable execution on request.
• Validation protocols & Instrumentation celebration.

VARIABLE SPEED AGITATION :
• Agitator can be top or bottom driven or magnetically driven.
• Propeller type, Anchor type provided with High speed disperser or rotor-stator homogenizer.
• Single or double mechanical seal.

FULLY AUTOMATIC LIQUID SYRUP MANUFACTURING PLANT CONSISTING OF :
• Sugar Charging / Transfer System.
• Sugar Melting Vessel with mixing stirrer.
• Basket Filter & Transfer Pump.
• Syrup Manufacturing Vessel with stirrer.
• Inline Homogenizer.
• Zero Hold up Filter press.
• Storage Tank with stirrer.
• Interconnecting pipeline.
• Transfer Pumps.
• Integrated automatic control panel.
• Working Platform.

TURN KEY PROCESS LINE :
• For production, filtration, transfer and storage solution.
• Pre reparation vessels.
• Inline homogenizer.
• Inter Connecting Pipe
• Solid or sugar Charging System
• Working Platform.

UNIQUE FEATURES OF THE FACILITY :
• The liquid oral manufacturing plant is designed to be operated by one operator and one helper, saving on precious man-power costs.
• Sugar syrup and manufacturing vessels are provided with limpet coils for heating and cooling, designed for internal vacuum to facilitate transfer of sugar directly from stores to sugar syrup vessel.
• Sugar syrup is transferred to manufacturing vessel through online sugar syrup prefilter by vacuum.
• Entries of all propeller agitators are from bottom through a specially designed cartridge mechanical seal with TC/TC seal face.
• The advantage of the bottom propeller agitator over the conventional agitator is that there are no vibrations of shaft, no couplings in the drive assembly, leading to lower maintenance cost for liquid oral manufacturing plant.
• Pipes, pipe fittings and valves are of SS 316, seamless, internally electro polished with DIN standard unions and silicon Gaskets.
• Manholes of all the vessels are equipped with davit fitting and the cover of the manhole slides instead of being lifted.

AUTOMATION AVAILABLE, APPROPRIATE FOR THE INTENDED PROCESS FUNCTION, INCLUDING CIP AND SIP :
• Controls of all function by PLC Controls with HMI Touch screen.
• Level controls by means of capacitance probe or electronic load cells.
• Digital indication and controls of all process parameters for Process time, agitator speed, temperature, pressure & level.

CAPACITIES AVAILABLE : 50 Ltrs to 15000 Ltrs

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Are you looking for a professional company specialising in the production of machines and equipment for the cosmetics industry, with bottling and packaging plants for your cosmetic products?

The Bombay Engineering Works is an Indian company specialising in the design and construction of machines for small, medium and large-sized business that operate in the chemical, pharmaceutical, cosmetics, food industries etc..
The Bombay Engineering Works is able to boast a very wide customer base of Indian and international clients due to a long history operating in many merchandise sectors.

The cosmetics industry is constantly evolving and changing, in order to offer its many customers products that are always new and original. This applies both to the raw materials used, that are increasingly safe, and the product's look that must be innovative, competitive and striking.

The Bombay Engineering Works supplies plants, machines and equipment for the cosmetics industry. The company has the capacity to design, develop and construct in-house automatic and semi-automatic machines, both in-line and rotary, for bottling, dosing and packaging operations.
Types of machines supplied include fillers, dosers and dispensers, cappers, crimpers, sealers, labellers, as well as machines for filtering, mixing and storage, such as filter presses, mixing tanks and storage tanks, agitators and turbo-emulsifiers.

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"Major components of Softgel Encapsulating Machine"

Softgel encapsulation machine is an indispensable mechanical device commonly used in softgel capsule and paintball making industries.

Listed below are the major components of softgel encapsulating machine and their respective functions-

a. Host machine
It is the most direct equipment unit used to complete soft capsule production. It is mainly composed of machine frame, machine head, material feeding pump, lifting device, pill feeder, gelatin skin wheels, gelatin coating system, lubrication system, conveyor, electric control box, control panels and other components.

b. Machine frame
It is the carrier for supporting and installing various functional components, and stainless steel coating is installed outside.

c. Machine head
It is used for installing the mould, and can drive the mould for synchronous rotation to complete the action of cutting pills. The rotation accuracy and synchronization accuracy of the machine head directly affect the moulding quality of pressure pills.

d. Material feeding pump
The feeding pump is fixed above the machine frame, it sucks the material liquid in the hopper, and sends the liquid into the switch board combination through four feed tubes, a part of material liquid is sprayed out from the wedge-shaped sprinkler body after being distributed of the shunting plate in the switch board combination, and the other material liquid can be sent back into the hopper along with the return hose.

e. Lifting device
It is installed in front of the material feeding pump and above the machine head, and is composed of switch board combination, and a sprinkler body combination is fixed on the lower end.

f. Gelatin skin wheel
The gelatin skin wheels are fixed on both sides of the machine frame with one on the left side and the other on the right side, cooling medium is sealed in the gelatin skin wheels, and the cooling medium commonly adopts clean water. Clean water can circulate in the gelatin skin wheel and the pipelines under the effect of circulating water pump of water cooling machine during work, meanwhile, the refrigeration system is started, the temperature can be set through the temperature control push button on the water cooling machine, the temperature of the gelatin skin wheels can be kept in the error range of the set value after certain time.

g. Gelatin coating system
It comprises tube pinching combinations, gelatin coating roll combination, and oil roll combination and carrier roller. The tube pinching combination is used for controlling turn-on and turn-off of the gelatin inlet. The gelatin coating roll combination, oil roll combination and carrier roll are fixed on the aluminium plate in front of the machine frame, the power of the gelatin coating roll combination is sent out by the main motor, the rose work shaft in the gelatin coating roll combination is rotated to tear off the prepared gelatin skin from the gelatin skin wheels, and send it into the oil roll. The oil roll can coat oil on the gelatin skin to play a role of protecting the gelatin skin. The carrier roll is used for supporting and guiding the gelatin skin.

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“Rapid Mix Granulator (Operation and Cleaning Guide) : The Bombay Engineering Works”

Operating principle :
A rapid mix granulator is a multi-purpose mixer/processor equally suitable for high speed dispersion of dry powders (including effervescent powders) and their granulation with aqueous or organic solvents. The equipment is designed to achieve rapid mixing and the formation of consistent granules required for the production of high quality pharmaceutical tablets for solid dosage forms of medication. Good mixing and control of granule size leads to fast tableting speeds and high quality products with low rejection rate.

A rapid mixer granulator usually comprises mixing bowl with a bottom entry agitator or impeller for mixing the materials and a side mounted chopper for granulating the mixture. The operating principle is based on agitation of the contents of the bowl at moderate speed and then running the blade of the chopper at high speeds to achieve granulation.

Broadly the operating process therefore takes place in 3 steps -
• Dry materials are mixed at high speed for typically 3 to 5 minutes.
• The mixer is set at a slow speed and liquid binder is added to the dry materials. Mixing of the wet materials typically takes a further 5-10 minutes. The impeller breaks up the mass of material into smaller fragments or granules.
• Wet granulation is achieved by running the mixer at high speed and it typically takes another 5 to 10 minutes to produce granules of 0.5 to 1.5 mm average diameter. The actual granulation time depends on the nature of the starting materials (e.g., density and particle size), the binder, and the speed of the chopper. In this step it is the design and speed of the chopper that determines the uniformity and size of the produced granules. The chopper runs at high speed usually above 200 rpm, and typically between 1200 and 2000 rpm.
Operating procedure :

A. Pre-start Up -
• Ensure that the processing area is clean.
• Check that the correct materials have been selected for the granulation process.
• Remove the “cleaned” label from the granulator after checking the information provided (especially previously used materials).
• Place the equipment label on the machine.

B. Start Up and operation -
• Use protective latex gloves when loading and unloading materials.
• Open the lid of the granulator and load the material to the bowl as per the sequence indicated in the Batch Manufacturing Record (BMR) or specification.
• Close the lid and secure the two locking clamps.
• Fix the dry mixing speed as specified in the BMR. Turn on the power and start the dry mixing process. Run for the specified mixing period.
• Slow the mixer impeller as specified in the BMR to the speed required for binder addition.
• Add the binder solution by supplying through the solution inlet port.
• Check the impeller speed is as per BMR and for the wet mixing process, and run for the required period.
• Increase the speed and set the chopper speed to that required for granulation. Check regularly to ensure that granulation is complete.
• Open the discharge gate and allow the wet mass to flow into a clean FBD bowl, located under the discharge port.

C. Shut Down -
• Stop the chopper and impeller, and open the equipment top lid. Remove any remaining mix by scraping it from the sides of the bowl.
• Check that all materials are removed.
• Switch off the main power supply.

Cleaning Procedures -
1. Cleaning during batch changeover, but with the same product -
• Check that the equipment and area around the equipment is clean.
• Remove the “cleaned” label from the machine.
• Place the equipment “in use” label on the machine.

2. Cleaning during product changeover -
• Check that the equipment and area around the equipment is clean and free from waste or materials from previous products.
• Check and review the “rinse water analysis report” and attach to the BMR.
• Remove the “cleaned” label from the machine.
• Check the relative humidity and room temperature, making sure to document it in the BMR log.
• If the temperature is not within the specified limit, inform the maintenance personnel and do not proceed until the temperature and relative humidity is changed to the required norm.

3. Cleaning at shutdown (e.g., end of day cleaning), or during batch changeover of same product (of ascending potency) -
• Use a vacuum cleaner or lint free cloth to remove loosely stuck powder.
• Dismantle the machine parts and remove them in sequence:
1) Agitator dome
2) Chopper blade
3) Stainless steel bolt
• Use a lint free cloth or vacuum cleaner to clean the dismantled parts.
• Clean the machine and disassemble the parts with lint free cloth.
• Clean the processing area as per the SOP.
• Assemble the parts once cleaned.
• Affix “cleaned” label to equipment.
• Document the cleaning details in the BMR log.

4. Cleaning at Product Changeover (same product of descending potency) – Preventative Maintenance of Contact Parts -
• Clean the mixer and the assembly surface using a moist duster followed by a dry clean duster.
• Fill the bowl with 1/3 of its capacity with water, close the lid and run the mixer and chopper for 5 minutes.
• Collect the washing water e.g., by placing stainless steel drum under the discharge port.
• Open the top lid, remove the agitator blade, and dome by loosening the locking nuts.
• Dismantle the chopper blade by loosening the belt and then remove the blade and washer.
• Transfer the agitator blade and chopper to the washing area, clean both items under a jet of water, and scrub using a clean nylon brush.
• Scrub sticky powder with nylon brush and wash the bowl thoroughly to remove any visible sign of material. .
• Check the underside of the chopper blade, dome and chopper crevices, discharge ports and locking nuts to make sure that the equipment is visibly clean.
• Rinse the machine and the parts with purified water. Send a sample of the rinse water to QA to confirm that it is free from materials from the previous batch.
• Place the “cleaned” label on the machine.
• Document the cleaning details in the BMR log.

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“What Can Ribbon Mixers Do For You? – THE BOMBAY ENGINEERING WORKS”

With benefits ranging from ease of cleaning to low energy use, ribbon mixers are an efficient solution for food manufacturers working with powder materials and ingredients.

When it comes to working with free-flowing or sticky powder material, ribbon mixers are a very popular solution throughout the food industry. With a simple structure, ease of cleaning, and low energy use, ribbon mixers are used by heavyweight food manufacturers like Kraft, General Mills, Pepsi, Mars, and many others. Here are some of the benefits and advantages, in greater detail, of ribbon mixers.

Straightforward Design :
Ribbon mixers employ a simplistic design and structure with a limited number of components. The mixer consists of a ribbon agitator, U-shaped vessel, two end plates, and a drive unit. Thanks to its straightforward design, the ribbon shaft can be easily cleaned and troubleshooting and maintenance are conveniently performed. Additionally, the smooth surface and rounded edges ensure any leftover residues can be easily removed.

Drive Unit :
Since the ribbon mixer is only a mild mixing machine, the shaft speed does not need to be fast and therefore does not require a high-powered motor for the drive unit. Additionally, just like the mixer’s overall structure, the structure of the drive unit is very simple and can be separated into a belt drive and direct connection drive. Another added benefit is that there is no risk of oil pollution into the product since the drive unit is located outside and away from the mixing vessel.

Seal Construction :
Food manufacturers prefer simple and effective seal structures that can be easily maintained and changed in the future. With this in mind, the ribbon mixer uses a split packing seal structure that allows for the quick and easy alteration of the packing seal, making the mixer adaptable to a variety of processes.

Discharge :
To reduce residue and limit the amount of wasted space, flap valves are the best choice for discharge. Slide gate valves and butterfly valves are effective options as well, but with roughly 80mm of height space, the flap valve tends to provide the most efficient spatial use, as the valve can lie flush with the bottom of the vessel.

Easy To Clean :
As mentioned earlier, the mixer is designed to be easily cleaned and maintained. The lid on the top of the ribbon mixer allows a worker to easily clean the machine from the top. Additionally, a safety grid and safety switch ensures that there is no potential for injuries to occur during cleaning.

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The Vacuum Tray Dryer is equipment used in the drying of the heat sensitive and hygroscopic materials.

DESCRIPTION :
Vacuum Tray Dryer is a modified form of the vacuum still. The Vacuum Tray Dryer which is in common use in the pharmaceutical industry is called vacuum oven. It consists of a jacketed vessel made of materials which can withstand vacuum with in the oven and steam pressure in the jacket.
The oven can be closed by a door that can be lacked tightly to provide an air tight seal.

The oven is connected to a vacuum pump through a condenser and a receiver. At the pressure of about 0.03 to 0.06 bars vacuum oven is operated generally.
At this pressure water boils at 25 -35 degree centigrade. In the pharmaceutical industry an oven of the size of about 1.5 m cubes having 20 shelves are commonly used.

Now days the vacuum ovens with a number of small compartments with small doors are available rather than one big compartments with a heavy door.

PRINCIPLE :
In Vacuum Tray Dryer materials is dried by the principle or applications of vacuum. The water boils at a lower temperature when the pressure is lowered by creating the vacuum. So evaporation of water takes place faster.

CONSTRUCTION :
The construction of the Vacuum Tray Dryer is made of with stand high vacuum pressure with cast iron heavy jacketed vessel which with stand the steam pressure in the jacket. It has enclosed space and divided in to 20 hollows shelves portions which are part of the jacket.
These shelves provide conduction of heat due to larger surface area about 45 to 50 m square provided by shelves and metal trays are placed over the shelves for keeping the materials. The oven door is locked tightly to give an air tight seal and is connected to a vacuum pump by placing condenser.

WORKING :
• The trays which are present in the dryer are used to dry the materials which are placed on the shelves and the pressure is decreased up to 30 to 60 kps by vacuum pump.
• Door is closed firmly and steam is passed through the space of jacket and shelves. So that the heat transfer takes place by the mechanism of conduction.
• Be vacuum evaporation the water is taken out from the material at 25 - 30 @c.
• Water vapour passes in to the condenser and after drying vacuum line is disconnected then the materials are collected from the trays.

PHARMACEUTICAL APPLICATIONS :
Vacuum Tray Dryer can be used for the drying of the following :
1. Heat sensitive materials, Dusty materials, hygroscopic materials, toxic materials can be dried in this vacuum dyer.
2. Feed materials containing the solvents are also dried by this vacuum dryer. The solvent material can be recovered by the condensation process.
3. Drugs which are required as porous end products.
4. Friable dry extracts can be obtained through this drying process.

ADVANTAGES :
1. Handling of the materials is easy in this drying because of tray arrangement inside the dryer.
2. It is easy for switching over to the next materials.
3. Hollow shelves which are electrically heated can be used.
4. It provides large surface area. So the heat can be easily transfer throughout the body of the dryer and fast drying action takes place.
5. Hot water can be supplied throughout the dryer which helps in drying process at the desired temperature.

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“Ointment Manufacturing Plant : The Bombay Engineering Works”

Ointment Manufacturing Plant is an ideal tool for the pharmaceutical & cosmetic industries for the production of Ointment, Cream, Lotions, Tooth Paste & other emulsions & homogenizations. It is specially designed to take care of two critical factors which directly affect the quality of the Ointment/Creams.

• Minimum man handling of Ointment.
• Negligible vacuum drop during mixing & blending.
• Needless to say, it also provides the benefits of the effective manpower utilization.
Features of Ointment Manufacturing Plant.
• Easily cleanable and completely untouched process, less chance of contamination.
• All contact parts made of Stainless Steel 316 and non- hence contact part ss 304 material.
• All pipelines are electro polished from inside and joints are easy openable.
• Complete cover lifting arrangement to facilitate cleaning at the time of product change over.
• Especially semi-contra & Double contra designed anchor stirrer with flexible Teflon scrapers.
• The plant is provided with pre-mixing wax and water phase vessels and the main manufacturing vessel.
• The main vessel is provided with a slow speed anchor agitator for mixing and a bottom high speed homogenizer for emulsifying.
• Variable speed drive provided for main anchor stirrer assembly for different speeds.
• Jacketed vessels for heating/cooling processes.
• Inspection glass with illumination.
• Specially designed inline filters can also be provided to ensure proper filtration.

Optional Requirement are :
1) Load cell for accurate weighing.
2) PLC based control panel for process automation.
3) Contra type agitator for calcium base toothpaste.
• The Ointment Manufacturing Plant / Cream Manufacturing Machine is suitable for manufacturing pharmaceutical ointments, sterile preparations, cosmetic creams, suspensions, gels, etc.

Equipments of Ointment Manufacturing Plant :
• Wax heating Vessel.
• Water Melting Vessel.
• Manufacturing vessel.
• Storage vessel.
• Interconnecting pipeline.
• Pumps -Lobe Pump and metering pumps.
• Integrated automatic control panel.
• Working Platform.
• Process Description of Ointment Manufacturing Plant :
• All vessels are manufactured from S.S. 316 grade stainless steel sheets and are cGMP compliant construction.
• The vessels are Jacketed, insulated, cladded and with suitable agitator assembly in each vessel.
• Wax is melted in Wax melting vessel; Water is heated in water heating vessel.
• Both wax and water are transferred into the manufacturing vessel automatically through vacuum.
• In manufacturing vessel both wax and water are homogenized to make a uniform emulsion and cooled by passing chilled water into the jacket of manufacturing vessel.
• After the emulsion is formed active ingredients/colors etc. are added and are thoroughly mixed and homogenized.
• The same is transferred by bump pump into the storage vessel. From the storage vessel it is automatically transferred into the filling machine by means of metering pump.
• Flow rate of metering pump can be set as per your tube filling machines speed and capacity.

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“Double Cone Blender : The Bombay Engineering Works”
Introduction :

Similar to the V-shape Mixing Machine, our Double Cone Blender is suitable for mixing highly flow-able powdery and granular materials, with superior mixing quality. Powdery or granular materials are fed into the double cone containers through vacuum intake or manual feeding. With the continuous rotation of the containers, the materials move in a complex and forceful manner to achieve uniform mixing.

Application Scope :
The double cone blender is applicable to mixing powdery and granular materials in the medicine, chemical, food, dye, building material, and fodder industries.

Features :
With the cylinder body made of stainless steel, and the inner and outer walls polished, our double cone blender has elegant design, and is sanitary, easy to clean. Also, the blender has the advantages of energy saving, easy operation, low labor intensity and high working efficiency.

The Double Cone Blender machine is used to produce homogeneous solid-solid mixture. Mixing is a common process step in the manufacture of products for industries such as healthcare, food, chemical, cosmetics, detergents, fertilizers and plastics.

Examples of materials or substances mixed in this way include pharmaceutical granules, semolina flour, seeds, starch, coffee beans and ground coffee, cocoa, chocolate flakes or granules, powdered milk, baby food, preparations to make dehydrated soups and creams, leaf waxes, detergent granules, soap flakes, artificial fertilizers, plastic in powder, ground or pellet form, fibre glass.

Operating principle :
• The main body of the blender consists of two cone-shaped sections welded at their bases to a central cylindrical section.
• The axis of rotation is perpendicular to the cone axis and passes through the cylindrical section.
• The driving motor is located at one of the two lateral supports holding the blender body.
• The solids are introduced into the blender through the loading aperture.
• In this type of blender, mixing takes place axially, as a result of the powder moving through the different sections.
• Mixing is thorough but it depends on the rotating speed.
• The mixture is discharged through a hermetically closing butterfly valve which can be operated manually or automatically.
• The unit is provided with a guard rail with electrical safety to prevent the operator from accessing it when in operation.
• If anyone should gain access to the unit, for safety reasons, the operation will cease.

Design and features :
• The series consists of 6 models with a total capacity of 160 to 4200 liters and a useful capacity of 65% of the total.
• This blender is especially designed for sensitive mixtures with risk of breakage where the generation of dusts is to be avoided.
• Mixing times vary between 5 and 20 minutes depending on the mixture.
• The interior of the blender incorporates a cone mounted on the pivot axis on both sides.
• This system eliminates the formation of dead spaces and facilitates gravity discharge.
• The unit is manufactured in AISI 316 (EN 14404) quality for all parts in contact with the product and AISI 304 (EN 14301) for the supports and the rest of the equipment.
• The internal and external surfaces have a bright polished finish.
• Due to the polished surface and absence of edges or corners, the unit can be easily cleaned either manually or automatically with CIP system.
• The unit incorporates a guard rail with electrical safety, according to EC safety standards.

Materials :
• Parts in contact with the product AISI 316 (EN 14404)
• Structure and other metal parts AISI 304 (EN 14301)
• Internal finish Bright polish
• External finish Bright polish

Options :
• This unit allows the incorporation of a liquid spray system to introduce liquids in spray form during the process.
• The injector is connected to the spray nozzles by means of a rotary system and is fed with additives from a pressurized tank or by means of a variable displacement pump at constant pressure.
• The automatic stop positions are: loading, discharging, and sampling. Before stopping at one of these three positions, the system performs a cycle which slows down the mixer in order to reach the stopping position with the highest possible accuracy and remains halted at that point.
• The unit can be equipped with an automated loading system for introducing powders and granules into the blender body by means of a vacuum unit with self-cleaning hoses. It prevents creation of dust.
• The skid can also be provided with a complete mono block vacuum unit with liquid ring pump.
• It is possible to install an automated vacuum discharge system. It includes a product receiving hopper with an automated self-cleaning filter; as well as a control panel for the unit.
• The loading/discharge can be carried out with pneumatically actuated retractable hermetic bellows. This system and the vacuum loading/discharge can be combined.

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THE ADVANTAGES OF V BLENDERS : THE BOMBAY ENGINEERING WORKS

Today, a variety of different types of blenders and mixers are available on the market for industrial and commercial use. As a result, it is important to ensure the selection of the right equipment for the application and industry in which it will be used.

Among the most popular types of blenders available for the pharmaceutical, chemical, food and beverage industries is the V blender. In deciding whether V blenders are the right choice, it is important to consider the advantages and disadvantages offered, as well as learn more about the most suitable applications for this type of equipment.

V blenders offer a number of advantages, including the fact that this type of blender can minimize particle size reduction due to the lack of any moving blades. As a result, V blenders are suitable for use with fragile materials. Additionally, this type of blender works to eliminate product contamination. The shape and design of the V blender also makes it quite easy to clean.

While V blenders do offer many advantages, there are some potential drawbacks, including the fact they are not typically suitable for mixing particles of different densities and sizes that could segregate when they are discharged.

V blenders are typically used in the dry blending of solids that are capable of free flowing. This is why this blender is often used in the pharmaceutical industry.

Additionally, V blenders may also be used with the following :
• Dry flavours
• Milk powders
• Food products
• Ceramics powders
• Coffee
• Animal feeds
• Pigments
• Herbicides and pesticides
• Fertilizers
• Spice blends
• Cosmetics
• Baby foods

Given their versatility and many advantages, V blenders can be an excellent addition to many industries. Developing a greater understanding of the most applicable uses for a V blender can help you to make a more informed decision.

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Working and principle of Rapid Mixer Granulator (RMG) -

Rapid Mixer Granulator is a multi-purpose processor equally suitable for high speed dispersion of dry powders, aqueous or solvent granulation, and effervescent products and melts palletisation.

Wet granulation is a common step in the manufacture of many solid dosage pharmaceuticals. Wet granulation can be accomplished in a mixer granulator. A mechanical impeller moves the powder while a liquid binder is applied onto a moving powder bed. Addition of the liquid binder starts the formation of granules. The granulator also has a chopper.
Impeller and chopper are mainly responsible for wet granulation in the rapid mixer granulator.

Rapid Mixer Granulator is designed to achieve excellent mixing and consistent granules at lower operating cost along with higher productivity. Better mixing and closed control of granule size leads to faster tableting speeds with improved quality and least rejections.

The granulation is conventionally performed in the following process steps :
• Mixing of dry material at high impeller and chopper speeds for a few minutes.
• Addition of liquid binder by pouring it on to the powder, while both the impeller and chopper are running at a low speed.
• Wet massing with both agitators running at high speed.

1) Impellers :
Impellers are fixed at the bottom of dome shaped stainless steel bowl. It has fully length and two half-length blades. Impellers are designed such a way that small blade lift the material and full length blades push the material to mix well. These impellers break up the wet mass into small pieces and granules.

2) Chopper :
These are specially designed small blades located at the bottom of the dome. The primary function of chopper is to cuts the lumps into smaller fragments those are mixed equally by impeller and aids the bowl or sprayed onto the powder to achieve a more homogeneous liquid distribution. It rotates at high speed (1440/2880) RPM to give easy and uniform granulation. The speed of chopper is responsible for the size of granule. Chopper does not have any significant effect on the granule size when impeller speed is high (above 200 RPM).

3) Discharge Port :
The discharge port is mounted horizontally into the dome with vertical downward opening. Granules are unloaded in the container through the discharge port. Opening of discharge port is operated by pneumatic cylinder (compressed air cylinder) that requires 3-5 kg/cm2 pressure of compress air.

4) Working Principle :
• The Rapid Mixer Granulator is mixing unit with a bottom entry agitator ad side mounted chopper for granulation. It is used for dry blending, wet mixing, preparation of dough and granulation, i.e. cutting of the wet mass into small size granules. It works on the basic principle of agitation of the contents of the bowl at moderate speed and then running a specially profiled cutter blade at high speeds into the wet mass.
• Dry mixing takes about 3-5 minutes to mix the ingredients; wet mixing takes 5-10 minutes to make the wet mass of material while the granulation process takes 5-10 minute to 0.5 mm to 1.5 mm sized granules.
• Mixing time consumed in processing is depends upon the ingredients quantity and their particle size.

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RIBBON BLENDER -

GENERAL SPECIFICATIONS OF “THE BOMBAY ENGINEERING WORKS” RIBBON BLENDER

OPERATION :
The RIBBON BLENDER is an efficient and versatile blending machine for mixing of dry granules & powders homogeneously. Approximate two third of the volume of the container of Ribbon Blender is filled to ensure proper mixing. The Ribbon Blender gives best result for mixing of dry powder & granules due to the design and shape of the mixing ribbon and product container. It can be used for Pharmaceutical, Food, Chemical and Cosmetic products etc.

Material should be charge from the top side. There are port/ports should be provided on the top cover to charge the material as well as for air vent. One discharge valve provided at the bottom side at center of the container. The discharge height could be adjusted as per the requirement, so that material gets discharge in the other container directly, so that material handling time for discharge is nil and the operation is dust free.

In Ribbon Blender the powder moves from center to the end of container and end of container to the center of container. Hence requirement of total mixing time is very less and the RPM required are also very less.

The dry material gets sufficient continuous movement due to the shape & movement of ribbon & shape of the container, Which moves material for good quality of blending.

The unit is consist of one electrical motor, one worm reduction gear, belt drive between motor and gear, couple drive between gear to ( ribbon ) mixing stirrer. Container having four nos. of legs with discharge valve & top cover. Both end of mixing shaft is sealed with bush & PTFE gland housing & safety guards are provided on all moving parts.

SALIENT FEATURES :
> The shape of container and mixing stirrer gives sufficient continuous movement to the powder / granules result in good quality.
> All contact parts are made out of SS304/SS316 quality material.
> Maximum care has been taken to ensure safe operation of the unit.
> Inching facility for stirrer for discharge of material.
> Full cover on top side of the container.
> Discharge height must be adjusted, if confirm with order.
> Operating panel provided for safe operation of blender.
> Centrally located material Discharge valve.
> Dust proof top cover with window provided.
> General structure completely made out of mild steel & painted in Standard Model & the same is cladded with SS304 in GMP model.
> Safety Guards & Covers made out of SS304 in GMP Model & made out of mild steel in Standard Model.
> Legs made out of M.S & painted in Standard Model & same will be cladded with SS304 in GMP Model.
> Automatic control Panel provided with the machine.
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"Advantages of Fluid Bed Dryer in Pharmaceutical Industry -
THE BOMBAY ENGINEERING WORKS"

Fluid bed dryer plays an integral role in the pharmaceutical industry. This is due to the many advantages that it offers over the conventional drying techniques.

So far, a number fluidized bed drying studies have established that it is the most reliable and dependable technique in the pharmaceutical industry.

With this information, you can comfortably choose the right pharmaceutical fluid bed dryer.

Advantages of Fluid Bed Dryer :
The available fluidized bed dryers offer a wide range of benefits depending on their unique design.

Below are the main advantages of fluidized bed dryers in the pharmaceutical industry :
1. Fluidized Bed Dryers Guarantee Fast and Homogeneous Drying
• The hot gas/air flows into the system with a velocity greater than the setting velocity of particles. This causes the particles to be suspended in the hot air or gas.
• In this fluidized state, the particle you intend to dry is actually in direct contact with the hot gas or air. Therefore, drying can be done within 10 to 40 minutes.
• Furthermore, the uniform drying is due to the fact that every particle of the solid is surrounded by hot air or gas.
• Whether you opt for a vertical or horizontal fluidized dryer, the working principle will still remain the same.

2. Fluid Bed Dryer is Suitable for Heat Sensitive Products
• Some powders and granules degrade or lose essential properties when subjected to extreme heat or temperatures.
• This makes the conventional drying systems unsuitable for such products.
• The modern fluidized bed designs have sensitive and effective sensors that monitor all essential parameters during material drying process.
• Even with the high rate of mass and heat transfer, you can still control the basic parameters that affect quality of the final product.
Fluid Bed Dryer Control Panel :
• With this control panel, you can easily monitor the temperature and air flow settings.
• That is, with the modern control system, you can adjust all parameters of the inlet air flow.

3. Fluidized Bed Ensures Efficiency in Material Drying
• The fluid bed dryer working principle is such that the particles are dried individually as opposed to the entire bed. Remember, the hot air or gas surrounds all particles and this ensures efficiency in the material drying process.
• Hot air or gas reaches every surface of the particles
• This guarantees 99.9% efficiency in the drying process while saving thermal heat.
• Normally, you’ll find that the thermal efficiency of fluid dryers is 3 times greater than those of other conventional drying systems.

4. Handling Fluidized Bed Dryer is Easy and Less Labor Intensive
• A number of fluid bed dryer designs are such that you can conveniently relocate them from one point to another. This makes handling these machines easy and less labor intensive.
• Furthermore, there are those that have wheels, making them portable material processing equipment.
A Fluid Bed Dryer with Wheels :
• This makes fluid bed dryer a perfect choice for most laboratory and R & D applications.

5. Fluid Bed Dryer Designs Come in a Wide Range of Capacities and Sizes
• Whether you’re in pharmaceutical, laboratory or R&D facility; there is that fluidized dryer design that will suit your unique application requirements. For instance, we have a wide range of fluid bed dryer equipment optimized for different applications.

6. Fluid Bed Dryer has Low Maintenance Cost hence, Reduces Downtime
• This is quite clear from the modular and cGMP compliant designs of our fluid bed dryers for pharmaceutical machines. The equipment is made from high quality stainless steel.
• Ideally, you don’t have to worry about product contamination, dust pollution, rust or tedious cleaning process.
• Furthermore, with the modular design, you can easily replace or modify this machine to suit your unique applications.
• NOTE: In case you have to modify our machines, kindly contact our technical team. Remember, hiring untrained personnel will make your warranty invalid.

7. No Hot Spots on the Final Products
• The hot spot is a common phenomenon in most drying equipment. This is because the products are in direct contact with the drying surface.
Fluid Bed Material Processing Chamber :
• All materials are suspended within the material drying chamber.
• Additionally, you can choose the right capacity of the fluid dryer where there is an excellent mixing of both the particles and air.
• Remember, in other drying applications, you cannot use high temperatures since this may cause damage to the product.
• However, for the case of fluid bed dryer, you can use high drying temperature.
• Again, due to the unique fluid bed dryer working principle; you can use this machine to dry thermolabile products. This is one of the main reasons why fluidization is common in most pharmaceutical industries.

8. Fluid Bed Dryer Is Suitable for both Continuous & Batch Material Processing
• Do you need a drying machine for both batch and continuous material processing?
• Well, I can recommend a fluidized bed dryer since it is a machine that can handle both processes without necessarily doing expensive adjustments or modifications.

Apart from these 8 advantages of fluid bed dryer, other includes :
• No risk of soluble substances migrating
• Reduced dust pollution
• Small size with high production capacity
• High rates of moisture removal

Even though a fluidized bed dryer may offer all these advantages; it may not be suitable for all pharmaceutical applications. It is for this reason that we may advise you to consider other alternatives.
Besides, even when you adopt fluid bed dryer, there are certain challenges that you’ll have to deal with.

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“Double Cone Blender : The Bombay Engineering Works”

Introduction :
Similar to the V-shape Mixing Machine, our Double Cone Blender is suitable for mixing highly flow-able powdery and granular materials, with superior mixing quality. Powdery or granular materials are fed into the double cone containers through vacuum intake or manual feeding. With the continuous rotation of the containers, the materials move in a complex and forceful manner to achieve uniform mixing.

Application Scope :
The double cone blender is applicable to mixing powdery and granular materials in the medicine, chemical, food, dye, building material, and fodder industries.

Features :
With the cylinder body made of stainless steel, and the inner and outer walls polished, our double cone blender has elegant design, and is sanitary, easy to clean. Also, the blender has the advantages of energy saving, easy operation, low labor intensity and high working efficiency.

The Double Cone Blender machine is used to produce homogeneous solid-solid mixture. Mixing is a common process step in the manufacture of products for industries such as healthcare, food, chemical, cosmetics, detergents, fertilizers and plastics.

Examples of materials or substances mixed in this way include pharmaceutical granules, semolina flour, seeds, starch, coffee beans and ground coffee, cocoa, chocolate flakes or granules, powdered milk, baby food, preparations to make dehydrated soups and creams, leaf waxes, detergent granules, soap flakes, artificial fertilizers, plastic in powder, ground or pellet form, fibre glass.

Operating principle :
• The main body of the blender consists of two cone-shaped sections welded at their bases to a central cylindrical section.
• The axis of rotation is perpendicular to the cone axis and passes through the cylindrical section.
• The driving motor is located at one of the two lateral supports holding the blender body.
• The solids are introduced into the blender through the loading aperture.
• In this type of blender, mixing takes place axially, as a result of the powder moving through the different sections.
• Mixing is thorough but it depends on the rotating speed.
• The mixture is discharged through a hermetically closing butterfly valve which can be operated manually or automatically.
• The unit is provided with a guard rail with electrical safety to prevent the operator from accessing it when in operation.
• If anyone should gain access to the unit, for safety reasons, the operation will cease.

Design and features :
• The series consists of 6 models with a total capacity of 160 to 4200 liters and a useful capacity of 65% of the total.
• This blender is especially designed for sensitive mixtures with risk of breakage where the generation of dusts is to be avoided.
• Mixing times vary between 5 and 20 minutes depending on the mixture.
• The interior of the blender incorporates a cone mounted on the pivot axis on both sides.
• This system eliminates the formation of dead spaces and facilitates gravity discharge.
• The unit is manufactured in AISI 316 (EN 14404) quality for all parts in contact with the product and AISI 304 (EN 14301) for the supports and the rest of the equipment.
• The internal and external surfaces have a bright polished finish.
• Due to the polished surface and absence of edges or corners, the unit can be easily cleaned either manually or automatically with CIP system.
• The unit incorporates a guard rail with electrical safety, according to EC safety standards.

Materials :
• Parts in contact with the product AISI 316 (EN 14404)
• Structure and other metal parts AISI 304 (EN 14301)
• Internal finish Bright polish
• External finish Bright polish

Options :
• This unit allows the incorporation of a liquid spray system to introduce liquids in spray form during the process.
• The injector is connected to the spray nozzles by means of a rotary system and is fed with additives from a pressurized tank or by means of a variable displacement pump at constant pressure.
• The automatic stop positions are: loading, discharging, and sampling. Before stopping at one of these three positions, the system performs a cycle which slows down the mixer in order to reach the stopping position with the highest possible accuracy and remains halted at that point.
• The unit can be equipped with an automated loading system for introducing powders and granules into the blender body by means of a vacuum unit with self-cleaning hoses. It prevents creation of dust.
• The skid can also be provided with a complete mono block vacuum unit with liquid ring pump.
• It is possible to install an automated vacuum discharge system. It includes a product receiving hopper with an automated self-cleaning filter; as well as a control panel for the unit.
• The loading/discharge can be carried out with pneumatically actuated retractable hermetic bellows. This system and the vacuum loading/discharge can be combined.

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“ZERO HOLD UP SPARKLER FILTER PRESS MANUFACTURERS IN INDIA – THE BOMBAY ENGINEERING WORKS”

We are leading at Zero Hold Up Sparkler Filter Press manufacturers in India. With experience and knowledge, we have built broad client base across worldwide. This Zero Hold Up Sparkler Filter Press machine is manufactured by us with very high quality material and as per the international industry standards to meet the changing needs.

Zero Hold Up Sparkler Filter Press manufacturers in India has been tested at various levels and it requires very low maintenance. The Zero Hold Up Sparkler Filter Press manufacturers in India consists of an assembly of filter plates and filter cloth with perforated S.S. supporting screens enclosed in an S.S. shell. The assembly is equipped with a pump to pressurize the liquid through the stack of horizontally arranged filter plates. With the help of our professionals, we are able to put forth widely appreciated zero hold sparkler filter press at pocket friendly prices.

Owing to our expertise in this domain, we are involved in offering a broad range of Zero Holdup Filter Press to our clients spanning Worldwide.

APPLICATION :
To filter final product in Pharmaceuticals, Perfumes, I. V. Fluids, Dyes & Chemicals, Activated carbon, Pesticides, Cosmetics, Varnishes, Polymers, Resins & Paints, Sugar syrup, Food, Plant Water Polishing, Fruit juice, Soft drink, Beer & Liquors, Edible & Non Edible oils.

SIZE AVAILABLE :
8” / 14” / 18” / 24” & 33” dia.

OPERATION :
• The liquid to be filtered is forced in the chamber by the Transfer pump, where it finds its way to the top of the filter media of each plate through circular opening on the side of the plates.
• Under pressure clear Liquid passes through the filter media leaving suspended particles on top of the filter.
• The clear filtrate runs down through central channel formed by the interlocking cups and exists through the outlet valve.

FEATURES :
• Single pass clear filtration.
• Full batch recovery of the filtrate.
• Easy install inside cartridge assembly.
• Complete cake retains on the plate.
• Uniform distribution of cake on each plate.
• Reduce the cost of treatment of catalyst, Toxic Chemicals.
• Less exposure to the operating person.
• No contamination of the internal surface of the shell.

ADVANTAGES :
• Zero retention in filter vessel.

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“Multicolumn Distillation Plant : The Bombay Engineering Works”

To industries where 100% pure Pyrogen - free water-for injection plays role, Multicolumn Distillation Plant is the perfect Multicolumn Distillation Plant solution. Available in capacities ranging from 80 - 5000 LPH, the Multicolumn Distillation Plant is used for its economy, low maintenance and low operation costs.

Some of the special features of Multicolumn Distillation Plant are:
• Pure Sterile Pyrogen free distilled water conforming to USP standards.
• Compact in design.
• All contact Parts are in SS 316 / SS 316 L.
• Electro polished crevice less inner contact surfaces.
• PLC based system for automated operation.
• Sanitary triclover fittings for quick and easy preventive maintenance.
• Double tube Sheet construction for the first column, where boiler steam is present.
• Synoptic panel board with facility for logging the data can also be given.

Multi Column Distillation Plant :
We offer a range of multi column distillation plants that are manufactured from high-grade raw material and have a capacity of 50 to 2500 ltrs.

APPLICATION :
To generate WFI water for injection / large volume of Parenteral.
CAPACITY : 50 to 2500 Ltrs.

TECHNICAL SPECIFICATION :
Distillate:
• IP/BP/USP specifications compliance.
• Distillate Temperature 95ºC
• Conductivity: Less than 0.5µ Siemens/cm.
• Endotoxin – Less than 0.25 Eu./ml.
• TOC – 100 PPB.

FEED WATER :
• Purified water with max. Conductivity of 0.5 microchips/cm. should be used.
• Pressure should be 1 kg/cm² higher than the in feed steam pressure.
• Temperature – Ambient 30ºC

COOLING WATER :
• Normal tap water is used
• Provided hardness is less than 90 PPM of CaCo3.
• Temperature – Ambient 30ºC

STEAM :
• Steam must be saturated, dry free from oil, vapours and other impurities.
(A steam filter to obtain 3µ, clear quality steam is recommended ask for details)
• Pressure –min steam pressure of 3 kg./cm² is essential to guarantee pyrogen-free distillate.

OPERATION :
• To feed purified water & heat with boiler steam & generate clean steam and condense with cool water which is WFI.

FEATURES :
• Energy Saving - Low operating cost.
• Compact Design - Space saving.
• All contact parts are SS 316L and all joints are sealed with Teflon Gasket.
• Fully Automatic operation - No Attendant required.

ADVANTAGES :
• Save water consumption & Boiler steam consumption.
• Complete close loop system. No air contamination.
• On line conductivity.
• If substandard conductivity will come dumping automatically through 3 way valve.

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“Tray dryers for drying wet, sticky or granulated products : The Bombay Engineering Works”

A range of technologies are used for food drying which include tray and tunnel dryers, spray, roller and freeze dryers. Tray dryers are quite suitable for drying wet chemicals, powders and crude drugs.

A simple tray dryer is a box-shaped cabinet in which a series of trays are inserted on shelves one on top of the other. Unlike an oven which perhaps has a heater in the base of the cabinet or walls, heat is supplied to a tray dryer by circulating air that has been heated either electrically or by some other means. One or more fans circulate the hot air over the trays.

The best tray dryers are those in which the air flow to the trays can be controlled. The materials to be dried are spread out on top of the trays which may be lined with paper. To shorten cleaning time and prevent contamination, disposable papers are used as tray liners. The trays are often supported on tiers made of wire mesh or perforated steel.

In the latest tray dryers, uniform temperature is achieved throughout a well-insulated cabinet by the use of strategically placed deflectors, which direct the air from one tray to pass over the tray above in the opposite direction.

Air flowing in alternate directions over the trays ensures uniformity of flow and helps to keep the temperature uniform. The air may also be reheated before it passes from one shelf to the next. Air that passes each shelf loses a certain amount of heat (the latent heat of vaporisation of the water that is expelled from the solid material).

Hot air therefore continuously circulates in a tray dryer, and the heat of the air removes the moisture from the material in the trays by forced convection. At the same time, moist air is expelled from the cabinet to vent.

Drying is commonly used after wet granulation. This is the process in which a tablet mix is turned in to a paste with water and then broken up in to granules. Granulation can increase the consistency and the followability of material in the tableting process.

Construction of a tray dryer :
There are several variants of tray dryer, ranging from simple manual systems ideal for batch processes through semi-automatic and automatic systems for processing large quantities.

The basic principles are the same in each case, as follows.
• The dryer consists of a heated box-shaped cabinet into which a number of trays can be loaded. The trays are rectangular or square in shape, typically between 1.2 and 2.4 m2 in area and up to 100 mm deep.
• A minimum of 3 trays can be often seen used in laboratory dryers; however industrial sized equipment may have up to 20 trays.
• The distance between trays and the material being loaded should be 40mm.
• Depending on the design of the dryer, several trays may be stacked on a ‘truck’ or trolley that provides the right separation between trays and which can be rolled in and out of the dryer. Alternatively trays can be inserted manually into runners in the dryer one at a time.
• Directional vanes are located inside the dryer to direct the air to circulate through the trays. In one design, the hot air passes over the bottom tray first, before passing over the second, and so on up to the top of the cabinet. In simple designs, the lower trays can therefore dry out first.

How it Works :
• Trays with wet solid materials are placed in the chamber.
• Fresh air is provided through the inlet and passes through the heater to be heated.
• The hot air is circulated by fans (typically at a rate of 3 to 5 m3/second).
• A turbulent flow or air can lower the vapour pressure of water in the air and reduce the air boundary layer thickness, thereby enhancing the drying effect of the hot air.
• Water diffuses from the interior of the porous material and evaporates from the surface of the solid matter.
• As the contact time is short (air flow rate is large), the amount of water evaporated in one pass through of air is relatively small.
• Some 80-90% of the air that has absorbed moisture from the material is recirculated to the inlet of the fans to mix with fresh dry air. Additional moisture is taken up by the air in the second and subsequent passes of air over the material.
• The moisture collected in the air is discharged through the outlet of the dryer. The high and uniform air flow ensures that there is a constant temperature within the dryer. These features help to achieve uniform drying of the solid matter.
• For wet granules such as tablets or capsules, the desired moisture content may be estimated by measuring the water that is discharged through the air outlet.
• The drying trays are then pulled out of the chamber and taken to the dump station.

Applications :
• Used for drying sticky materials
• Can be used for drying of crystalline or granular material
• Wet mass, paste, powders, and chemicals can all be dried
• A variety of small equipment may also be dried in tray dryers

Advantages :
• Loading and unloading of materials can be done without any losses.
• Batch drying is widely used by pharmaceutical companies.
• Each batch is treated as separate entity.
• Batch size can be small e.g., 250kg or less per batch (pharmaceutical) and 1000kg (chemical).
• Valuable products can be handled efficiently without loss, especially using the truck trays.

Vacuum Tray Dryer :
• A vacuum tray dryer is used mainly for drying of high grade, temperature and oxygen sensitive products. It is suitable for drying hygroscopic substances, which are dried to a very low residual moisture content. Vacuum drying cabinets are often the only means of drying lumpy, glutinous products or products of low porosity.
• As with the normal tray dryer, a vacuum dryer is box-shaped into which trays are loaded and unloaded via a door that has a vacuum seal around the edges. Inside are several heating plates mounted one above the other on above which the trays are placed.
• Since the trays sit directly on the heating plates, the surfaces of each should be as smooth as possible to allow good heat transfer between the heating plates and trays.
• Hot water, steam or oil flow inside the heating plates to provide the heat required for drying.
• The cabinet walls may also be heated by the circulating fluid to prevent condensation of water are indirectly preheated by the heating plates.

When the dryer is loaded with materials it is first heated at atmospheric pressure. Only after all individual product trays reach the same temperature is the cabinet is evacuated and drying commenced. The initial heating phase is necessary to enable a uniform temperature and drying conditions to be established throughout the cabinet. During the main drying phase the vacuum is in the range of 40 to 80 mbar abs.
This may be reduced to a few mbar in the final stages of drying.

Heating temperatures within a vacuum dryer can be much higher than an air dryer, and are often in the range between 800°C and 1100°C. Some systems allow automatic programming of both temperature and vacuum profiles. On completion of the drying, the product can be cooled by circulating of cooling water through the heating plates.

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“Rapid Mix Granulator (Operation and Cleaning Guide) : The Bombay Engineering Works”

Operating principle :
A rapid mix granulator is a multi-purpose mixer/processor equally suitable for high speed dispersion of dry powders (including effervescent powders) and their granulation with aqueous or organic solvents. The equipment is designed to achieve rapid mixing and the formation of consistent granules required for the production of high quality pharmaceutical tablets for solid dosage forms of medication. Good mixing and control of granule size leads to fast tableting speeds and high quality products with low rejection rate.

A rapid mixer granulator usually comprises mixing bowl with a bottom entry agitator or impeller for mixing the materials and a side mounted chopper for granulating the mixture. The operating principle is based on agitation of the contents of the bowl at moderate speed and then running the blade of the chopper at high speeds to achieve granulation.

Broadly the operating process therefore takes place in 3 steps -
• Dry materials are mixed at high speed for typically 3 to 5 minutes.
• The mixer is set at a slow speed and liquid binder is added to the dry materials. Mixing of the wet materials typically takes a further 5-10 minutes. The impeller breaks up the mass of material into smaller fragments or granules.
• Wet granulation is achieved by running the mixer at high speed and it typically takes another 5 to 10 minutes to produce granules of 0.5 to 1.5 mm average diameter. The actual granulation time depends on the nature of the starting materials (e.g., density and particle size), the binder, and the speed of the chopper. In this step it is the design and speed of the chopper that determines the uniformity and size of the produced granules. The chopper runs at high speed usually above 200 rpm, and typically between 1200 and 2000 rpm.

Operating procedure :
A. Pre-start Up -
• Ensure that the processing area is clean.
• Check that the correct materials have been selected for the granulation process.
• Remove the “cleaned” label from the granulator after checking the information provided (especially previously used materials).
• Place the equipment label on the machine.

B. Start Up and operation -
• Use protective latex gloves when loading and unloading materials.
• Open the lid of the granulator and load the material to the bowl as per the sequence indicated in the Batch Manufacturing Record (BMR) or specification.
• Close the lid and secure the two locking clamps.
• Fix the dry mixing speed as specified in the BMR. Turn on the power and start the dry mixing process. Run for the specified mixing period.
• Slow the mixer impeller as specified in the BMR to the speed required for binder addition.
• Add the binder solution by supplying through the solution inlet port.
• Check the impeller speed is as per BMR and for the wet mixing process, and run for the required period.
• Increase the speed and set the chopper speed to that required for granulation. Check regularly to ensure that granulation is complete.
• Open the discharge gate and allow the wet mass to flow into a clean FBD bowl, located under the discharge port.

C. Shut Down -
• Stop the chopper and impeller, and open the equipment top lid. Remove any remaining mix by scraping it from the sides of the bowl.
• Check that all materials are removed.
• Switch off the main power supply.

Cleaning Procedures -
1. Cleaning during batch changeover, but with the same product -
• Check that the equipment and area around the equipment is clean.
• Remove the “cleaned” label from the machine.
• Place the equipment “in use” label on the machine.

2. Cleaning during product changeover -
• Check that the equipment and area around the equipment is clean and free from waste or materials from previous products.
• Check and review the “rinse water analysis report” and attach to the BMR.
• Remove the “cleaned” label from the machine.
• Check the relative humidity and room temperature, making sure to document it in the BMR log.
• If the temperature is not within the specified limit, inform the maintenance personnel and do not proceed until the temperature and relative humidity is changed to the required norm.

3. Cleaning at shutdown (e.g., end of day cleaning), or during batch changeover of same product (of ascending potency) -
• Use a vacuum cleaner or lint free cloth to remove loosely stuck powder.
• Dismantle the machine parts and remove them in sequence:
1) Agitator dome
2) Chopper blade
3) Stainless steel bolt
• Use a lint free cloth or vacuum cleaner to clean the dismantled parts.
• Clean the machine and disassemble the parts with lint free cloth.
• Clean the processing area as per the SOP.
• Assemble the parts once cleaned.
• Affix “cleaned” label to equipment.
• Document the cleaning details in the BMR log.

4. Cleaning at Product Changeover (same product of descending potency) – Preventative Maintenance of Contact Parts -
• Clean the mixer and the assembly surface using a moist duster followed by a dry clean duster.
• Fill the bowl with 1/3 of its capacity with water, close the lid and run the mixer and chopper for 5 minutes.
• Collect the washing water e.g., by placing stainless steel drum under the discharge port.
• Open the top lid, remove the agitator blade, and dome by loosening the locking nuts.
• Dismantle the chopper blade by loosening the belt and then remove the blade and washer.
• Transfer the agitator blade and chopper to the washing area, clean both items under a jet of water, and scrub using a clean nylon brush.
• Scrub sticky powder with nylon brush and wash the bowl thoroughly to remove any visible sign of material. .
• Check the underside of the chopper blade, dome and chopper crevices, discharge ports and locking nuts to make sure that the equipment is visibly clean.
• Rinse the machine and the parts with purified water. Send a sample of the rinse water to QA to confirm that it is free from materials from the previous batch.
• Place the “cleaned” label on the machine.
• Document the cleaning details in the BMR log.

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“Tablet Inspection Machine (Operation And Cleaning Guide) : The Bombay Engineering Works”

To ensure consistent high quality of tablet production it is necessary to inspect each and every tablet produced by a tableting machine. Machines have been available for many years that can assist in the manual inspection of tablets. These feed the tablets from a chute onto a conveyor that vibrates or rotates the tablets through 360 degrees so that physical defects can be identified by an operator.

Most recently with the introduction of digital image recognition technology and software, machines are available that can automatically identify and reject tablets that have defects. For either manual or automatic inspection machines, it is essential that the equipment is thoroughly cleaned before starting the inspection of any new batch of tablets. The following is a brief guide that can be applied to the operation and cleaning of most tablet inspection machines.

Pre Start Up :
1) Check that the area in which the inspection machine is located and ensure that the machine is clean, and there are no remnants of previous products in the area or in the equipment.
2) Check the relative humidity and temperature of the work area and document it in the logbook.
3) If the temperature is not within the allowable limits, inform the maintenance, department and do not start the operation.
4) If temperature is within limits, start the inspection operation.
5) Ensure that the equipment is correctly labelled for the particular batch of product.
6) Get line approval from Quality Assurance (QA) department to start the process.

Operation :
1) Switch the mains electricity ON.
2) Check for any abnormal noise by pushing the start button.
3) To collect the inspected tablets, place tared polythene lined duly labelled high-density polyethylene container below the machine’s discharge chute.
4) Place the required batch of tablets into a trolley and place trolley near the inspection machine.
5) Manually feed the tablets to the machine’s hopper.
6) Set the vibration or rotation of the conveyor as required.
7) Switch on the conveyor belt.
8) In the case of manual inspection, check for any defects on the tablet as the move along the conveyor.
9) Collect the recoverable rejected tablets from the rejection box and place into a polyethylene container.
10) When the container at the discharge chute fills up, replace it with a similar container.
11) Remove the container and close the bag with a tie band, and place it in a different trolley to the product.

Shut Down :
1) When the tablet inspection is complete, switch the machine off.
2) Isolate the main electricity supply.
3) Move the product tablets to the intended placement area.
4) Remove the machine status label and dispose of it.
5) Place a “to be cleaned” label on the machine.

Cleaning :
1) Remove the “to be cleaned” and tear the label after checking the information on it.
2) Clean the machine hopper and conveyor belt using lint free cloth dipped in purified water.
3) Send a rinse sample to the in-process QA department.
4) Clean the machine with line free cloth dipped in purified water and dry with lint free cloth.
5) Clean the equipment body with dry lint free cloth.

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“What Can Ribbon Mixers Do For You? – THE BOMBAY ENGINEERING WORKS”

With benefits ranging from ease of cleaning to low energy use, ribbon mixers are an efficient solution for food manufacturers working with powder materials and ingredients.

When it comes to working with free-flowing or sticky powder material, ribbon mixers are a very popular solution throughout the food industry. With a simple structure, ease of cleaning, and low energy use, ribbon mixers are used by heavyweight food manufacturers like Kraft, General Mills, Pepsi, Mars, and many others. Here are some of the benefits and advantages, in greater detail, of ribbon mixers.

Straightforward Design :
Ribbon mixers employ a simplistic design and structure with a limited number of components. The mixer consists of a ribbon agitator, U-shaped vessel, two end plates, and a drive unit. Thanks to its straightforward design, the ribbon shaft can be easily cleaned and troubleshooting and maintenance are conveniently performed. Additionally, the smooth surface and rounded edges ensure any leftover residues can be easily removed.

Drive Unit :
Since the ribbon mixer is only a mild mixing machine, the shaft speed does not need to be fast and therefore does not require a high-powered motor for the drive unit. Additionally, just like the mixer’s overall structure, the structure of the drive unit is very simple and can be separated into a belt drive and direct connection drive. Another added benefit is that there is no risk of oil pollution into the product since the drive unit is located outside and away from the mixing vessel.

Seal Construction :
Food manufacturers prefer simple and effective seal structures that can be easily maintained and changed in the future. With this in mind, the ribbon mixer uses a split packing seal structure that allows for the quick and easy alteration of the packing seal, making the mixer adaptable to a variety of processes.

Discharge :
To reduce residue and limit the amount of wasted space, flap valves are the best choice for discharge. Slide gate valves and butterfly valves are effective options as well, but with roughly 80mm of height space, the flap valve tends to provide the most efficient spatial use, as the valve can lie flush with the bottom of the vessel.

Easy To Clean :
As mentioned earlier, the mixer is designed to be easily cleaned and maintained. The lid on the top of the ribbon mixer allows a worker to easily clean the machine from the top. Additionally, a safety grid and safety switch ensures that there is no potential for injuries to occur during cleaning.

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The Vacuum Tray Dryer is equipment used in the drying of the heat sensitive and hygroscopic materials.

DESCRIPTION :
Vacuum Tray Dryer is a modified form of the vacuum still. The Vacuum Tray Dryer which is in common use in the pharmaceutical industry is called vacuum oven. It consists of a jacketed vessel made of materials which can withstand vacuum with in the oven and steam pressure in the jacket.
The oven can be closed by a door that can be lacked tightly to provide an air tight seal.

The oven is connected to a vacuum pump through a condenser and a receiver. At the pressure of about 0.03 to 0.06 bars vacuum oven is operated generally.
At this pressure water boils at 25 -35 degree centigrade. In the pharmaceutical industry an oven of the size of about 1.5 m cubes having 20 shelves are commonly used.

Now days the vacuum ovens with a number of small compartments with small doors are available rather than one big compartments with a heavy door.

PRINCIPLE :
In Vacuum Tray Dryer materials is dried by the principle or applications of vacuum. The water boils at a lower temperature when the pressure is lowered by creating the vacuum. So evaporation of water takes place faster.

CONSTRUCTION :
The construction of the Vacuum Tray Dryer is made of with stand high vacuum pressure with cast iron heavy jacketed vessel which with stand the steam pressure in the jacket. It has enclosed space and divided in to 20 hollows shelves portions which are part of the jacket.

These shelves provide conduction of heat due to larger surface area about 45 to 50 m square provided by shelves and metal trays are placed over the shelves for keeping the materials. The oven door is locked tightly to give an air tight seal and is connected to a vacuum pump by placing condenser.

WORKING :
• The trays which are present in the dryer are used to dry the materials which are placed on the shelves and the pressure is decreased up to 30 to 60 kps by vacuum pump.
• Door is closed firmly and steam is passed through the space of jacket and shelves. So that the heat transfer takes place by the mechanism of conduction.
• Be vacuum evaporation the water is taken out from the material at 25 - 30 @c.
• Water vapour passes in to the condenser and after drying vacuum line is disconnected then the materials are collected from the trays.

PHARMACEUTICAL APPLICATIONS :
Vacuum Tray Dryer can be used for the drying of the following :
1. Heat sensitive materials, Dusty materials, hygroscopic materials, toxic materials can be dried in this vacuum dyer.
2. Feed materials containing the solvents are also dried by this vacuum dryer. The solvent material can be recovered by the condensation process.
3. Drugs which are required as porous end products.
4. Friable dry extracts can be obtained through this drying process.

ADVANTAGES :
1. Handling of the materials is easy in this drying because of tray arrangement inside the dryer.
2. It is easy for switching over to the next materials.
3. Hollow shelves which are electrically heated can be used.
4. It provides large surface area. So the heat can be easily transfer throughout the body of the dryer and fast drying action takes place.
5. Hot water can be supplied throughout the dryer which helps in drying process at the desired temperature.

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V Blenders :
The V Blender is a popular tumble blender commonly used in the pharmaceutical and food industries.

V-Blender - Construction and Operation :
There are three popular shapes of tumble blenders: the V Blender, the double cone, and the slant cone. Tumble blenders rely upon the action of gravity to cause the powder to cascade within a rotating vessel. The V Blender (also known as a twin shell blender) is one of the most commonly used tumbling blenders. The blending performance of this type of blender has shadowed many of the members in the blender family. They offer both short blending times and efficient blending.

The V-Blender is made of two hollow cylindrical shells joined at an angle of 75° to 90°. The blender container is mounted on trunnions to allow it to tumble. As the V blender tumbles, the material continuously splits and recombines, with the mixing occurring as the material free-falls randomly inside the vessel. The repetitive converging and diverging motion of material combined with increased frictional contact between the material and the vessel's long, straight sides result in gentle yet homogenous blending.

The primary mechanism of blending in a V Blender is diffusion. Diffusion blending is characterized by small scale random motion of solid particles. Blender movements increase the mobility of the individual particles and thus promote diffusive blending. Diffusion blending occurs where the particles are distributed over a freshly developed interface. In the absence of segregating effects, the diffusive blending will in time lead to a high degree of homogeneity.

V Blenders are therefore preferred when precise blend formulations are required. They are also well suited for applications where some ingredients may be as low as five percent of the total blends size. Normal blend times are typically in the range of 5 to 15 minutes depending on the properties of material to be blended.

The charging of material into the V Blender is through either of the two ends or through the apex port. Studies on V blenders have demonstrated that for solid powders which have similar size and shape, there is no mechanism to move the powders across the line of symmetry of the blender. For such materials, care must then be taken to load each side of the blender equally to ensure the desired homogeneity of blends.

Blending efficiency is affected by the volume of the material loaded into the blender. The recommended fill-up volume for the V-Blender is 50 to 60% of the total blender volume. For example, if the fill of material in the blender is increased from 50% of the total volume to 70% of the total volume, the time taken for homogenous blending may be doubled.

Blender speed may also be a key to mixing efficiency. At lower blender speeds, the shear forces are low. Though higher blending speeds provide more shear, it can lead to greater dusting resulting in segregation of fines. This means that the fines become air-borne and settle on top of the powder bed once the blender has been stopped. There is also a critical speed which, if approached will diminish blending efficiency considerably. As the revolutions per minute increase, the centrifugal forces at the extreme points of the blender will exceed the gravitation forces required for blending.

Consequently the powder shall tend to gravitate to the outer walls of the blender shell. As the size of the blender increases, the rotational speed decreases usually in proportion to the peripheral speed of the blender extreme. V-Blenders are designed to operate at 50% to 80% of the critical speed.

Discharge from the V-blender is normally through the apex port which is fitted with a discharge valve.
• Advantages of V-Blender :
• Particle size reduction and attrition are minimized due to the absence of any moving blades. Hence it can be used for fragile materials
• Charging and discharging of material is easy.
• The shape of blender body results in a near complete discharge of product material, clearly an added advantage over horizontal blenders.
• The absence of shaft projection eliminates product contamination.
• V-blenders are easy to clean.
• V-Blender with Intensifier Bar :

A V-Blender can be provided with high-speed intensifier bars (or lump breakers) running through trunnions into the vessel, along with spray pipes for liquid addition. The intensifiers may be provided for disintegration of agglomerates in the charge material or those formed during wet mixing. Figure 2 is a schematic drawing of the V-Blender with the intensifier bar.

Provision of the intensifier bars makes the V-Blender adaptable for more applications.
These include:
• Ability to accomplish dry as well as wet mixing.
• Suitability for mixing of fine as well as course particle compositions.
• Suitability for mixing of cohesive powders.

Applications of V-Blenders :
V-Blenders designs are most often used for the dry blending of free flowing solids. This blender is often used for pharmaceuticals, but the mixing action's slight shear limits the blender's use for some very soft powders or granules.

V-Blenders are generally used for the following:
• Food products
• Milk powder
• Coffee
• Dry flavours
• Ceramics Powders
• Pigments
• Pesticides and Herbicides
• Plastic powders
• Animal feeds
• Spice blends
• Fertilizers
• Baby foods
• Cosmetics
• Polyethylene

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“Ointment Manufacturing Plant : The Bombay Engineering Works”

Ointment Manufacturing Plant is an ideal tool for the pharmaceutical & cosmetic industries for the production of Ointment, Cream, Lotions, Toothpaste & other emulsions & homogenizations.

It is specially designed to take care of two critical factors which directly affect the quality of the Ointment/Creams.
• Minimum man handling of Ointment.
• Negligible vacuum drop during mixing & blending.
• Needless to say, it also provides the benefits of the effective manpower utilization.
Features of Ointment Manufacturing Plant.
• Easily cleanable and completely untouched process, less chance of contamination.
• All contact parts made of Stainless Steel 316 and non- hence contact part ss 304 material.
• All pipelines are electro polished from inside and joints are easy openable.
• Complete cover lifting arrangement to facilitate cleaning at the time of product change over.
• Especially semi-contra & Double contra designed anchor stirrer with flexible Teflon scrapers.
• The plant is provided with pre-mixing wax and water phase vessels and the main manufacturing vessel.
• The main vessel is provided with a slow speed anchor agitator for mixing and a bottom high speed homogenizer for emulsifying.
• Variable speed drive provided for main anchor stirrer assembly for different speeds.
• Jacketed vessels for heating/cooling processes.
• Inspection glass with illumination.
• Specially designed inline filters can also be provided to ensure proper filtration.

Optional Requirement are :
1) Load cell for accurate weighing.
2) PLC based control panel for process automation.
3) Contra type agitator for calcium base toothpaste.
• The Ointment Manufacturing Plant / Cream Manufacturing Machine is suitable for manufacturing pharmaceutical ointments, sterile preparations, cosmetic creams, suspensions, gels, etc.

Equipments of Ointment Manufacturing Plant :
• Wax heating Vessel.
• Water Melting Vessel.
• Manufacturing vessel.
• Storage vessel.
• Interconnecting pipeline.
• Pumps -Lobe Pump and metering pumps.
• Integrated automatic control panel.
• Working Platform.
• Process Description of Ointment Manufacturing Plant :
• All vessels are manufactured from S.S. 316 grade stainless steel sheets and are cGMP compliant construction.
• The vessels are Jacketed, insulated, cladded and with suitable agitator assembly in each vessel.
• Wax is melted in Wax melting vessel; Water is heated in water heating vessel.
• Both wax and water are transferred into the manufacturing vessel automatically through vacuum.
• In manufacturing vessel both wax and water are homogenized to make a uniform emulsion and cooled by passing chilled water into the jacket of manufacturing vessel.
• After the emulsion is formed active ingredients/colors etc. are added and are thoroughly mixed and homogenized.
• The same is transferred by bump pump into the storage vessel. From the storage vessel it is automatically transferred into the filling machine by means of metering pump.
• Flow rate of metering pump can be set as per your tube filling machines speed and capacity.

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“Contra Rotating Mixers : THE BOMBAY ENGINEERING WORKS”

Contra rotating mixers are typically used when thick emulsions are produced by a bottom entry emulsifier or homogenizer. They are also very useful for multi task vessels where different process duties are required.

Advantages :
Contra rotating mixers have the advantage of utilizing the benefits of a turbine unit with the benefits of an anchor / scraper. Contra rotating mixers offer excellent mixing throughout the vessel as viscosities increase due to their double mix system.

A contra rotating mixer is fitted with two drives; an anchor / scraper drive and a centrally mounted turbine drive. In effect it is two mixers joined together. The wet end can be complete and installed into the tank prior to the vessel being completed or can be fully split to allow simple installation / removal.

Areas of Applications :
The mixer is highly versatile and mostly used for manufacturing Toothpaste, Creams, Cosmetics and other viscous products.

Operation Principles :
Contra Mixer as the name suggests works on the principle of Contra rotation of Blades for simultaneous beating and scraping operation. The Mixing Assembly consists of series of paddle type blades of appropriate shape to move the material back towards the centre of the container.

The paddle type blades are provided on the central shaft which runs through a hollow shaft on which other sets of blades are welded. Both the sets of blades intermeshes with each other and rotates in clockwise and anti-clockwise direction respectively and one sets also scraps the container wall for thorough and uniform mixing of the material.

The mixer is so designed to withstand high vacuum applied during the process for optimum mixing. Contra Mixer is provided with a jacket for cooling or heating as per the application. The vessel shall have a shell of suitable thickness with a hemispherical bottom and flanged top dish made out of SS 316 plate.

The vessel shall be jacketed with MS jacket (SS 304 jacket provided on extra cost on demand, if required) of suitable with stiffeners suitable for steam pressure of 4 to 5 Kg/cm2. The jacket shall be insulated with 50 mm thick glass wool insulation and shall be cladded with 16 SWG M.S. or SS 304 materials. The vessel shall be suitable for 600 to 700 mm of Hg vacuum and internal pressure of 3 Kgs / cm2.

Salient Features :
• All contact parts AISI 304 or 316,304L or 316L.
• Jacketed mixers are provided for heating of products during mixing.
• Provision to mix / blend the viscous products under vacuum for de-aeration purpose.
• High shearing action because of contra rotary motion & homogenizer.
• Mechanical seal is provided instead of stuffing box for main shaft sealing for vacuum operation.
• Anchor blade assembly with adjustable Teflon scrappers is provided to avoid localized heating & ensure uniform mixing.
• Top drive & agitator assembly can be lifted & lowered by motorized as well as hydraulic operations if required.
• Smaller version of Contra Rotary Mixers is provided with lifting arrangement for the bowl instead of top drive & agitator assembly.
• Pneumatic system is also available for lifting & lowering top drive & agitator assembly for smaller version of Contra Mixer.
• Available in Standard Model and GMP Models.
• Capacity Available : 50 to 10,000 Ltrs.

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THE ADVANTAGES OF V BLENDERS : THE BOMBAY ENGINEERING WORKS

Today, a variety of different types of blenders and mixers are available on the market for industrial and commercial use. As a result, it is important to ensure the selection of the right equipment for the application and industry in which it will be used.

Among the most popular types of blenders available for the pharmaceutical, chemical, food and beverage industries is the V blender. In deciding whether V blenders are the right choice, it is important to consider the advantages and disadvantages offered, as well as learn more about the most suitable applications for this type of equipment.

V blenders offer a number of advantages, including the fact that this type of blender can minimize particle size reduction due to the lack of any moving blades. As a result, V blenders are suitable for use with fragile materials. Additionally, this type of blender works to eliminate product contamination. The shape and design of the V blender also makes it quite easy to clean.

While V blenders do offer many advantages, there are some potential drawbacks, including the fact they are not typically suitable for mixing particles of different densities and sizes that could segregate when they are discharged.
V blenders are typically used in the dry blending of solids that are capable of free flowing. This is why this blender is often used in the pharmaceutical industry.

Additionally, V blenders may also be used with the following :
• Dry flavours
• Milk powders
• Food products
• Ceramics powders
• Coffee
• Animal feeds
• Pigments
• Herbicides and pesticides
• Fertilizers
• Spice blends
• Cosmetics
• Baby foods

Given their versatility and many advantages, V blenders can be an excellent addition to many industries. Developing a greater understanding of the most applicable uses for a V blender can help you to make a more informed decision.

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Communiting Mill :
Comminuting Mill is with latest innovation in design, it's advantage is minimum product exposure to operator and environment. Versatile in operation with minimum maintenance. Even, for switching from knife to impact is accomplished simply by reversing the rotor assembly.
The flexibility, efficiency and precision of comminuting mill makes it suitable for variety of applications in pulverisation of material.

Application & Process :
Comminuting mill is used for the downsizing, milling, pulverization and dispersion of wet and dry products in pharmaceutical, chemical, food, cosmetics, fertilizers industry etc.

The product is poured from the top through in feed hopper and material falls on the rotor blades beater assembly for milling or pulverization. Due to the knife edges mounted on rotor, the downsizing of particle takes place and through sieve material gets pushed outward from the bottom opening. Knife edges can be removed for cleaning very easily.

Rotor / Blade Assembly :
At the heart of each Comminuting mill is a rotor and blade assembly Blades may be fixed or swinging, and can be either knife-edged for gentle granulation or impact edged for more aggressive reduction. Blades with one edge type on either side are also available for versatility. A variety of blade profiles assure the best match for your product requirements.

Optional :
• Water Jacked Model
• S.S.316 in place of S.S.304 contact parts
• Flame proof electrical fittings
• Compact and easily cleanable
• GMP model in place of standard model
• Various types of blades styles for desired application

Salient Features :
• For small, medium or large scale production
• Chamber accessibility for easy cleaning, inspection & maintenance
• Beater assembly is a dynamically balance rotor for reduction of vibration & noise level Castor wheel for easy mobility
• Reversible starter provided for dual operation
• Advanced rugged design requires very little maintenance
• Easy to clean and can be used for various kinds of products

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“Working and Principle of Colloidal Mill : THE BOMBAY ENGINEERING WORKS”

Colloidal mill is used to make the colloidal solution or reduce the particles size of the pharmaceutical ingredients in pharmaceutical manufacturing.

Pharmaceutical companies work with small compound particles. They seek to separate chemical compounds to get to the smallest state of the compounds. That is why the colloidal mill is important in the pharmaceutical manufacturing industries.

This is a machine that is used to reduce the size of particles of solids that are suspended in a liquid. When a liquid is suspended in another liquid, meaning that they are immiscible, this machine is used alternatively to reduce the size of this droplet.

Simply put the colloidal mill is used to solids present in suspensions and emulsions or even the suspensions size. It is used in the reduction of almost all types of materials. The end result of this type of mix is a very stable mix which is able to resist contamination by water or bleed. In fact, this is the method used in mixing cement based grout. The colloidal mill uses a method known as shearing.

Principle of the Colloidal Mill :
The basic principle used in the colloidal mill is known as rotor-stator which is placed in a cylindrical vessel. The rotor and stator are placed close enough to create a narrow passage where the material to be reduced in size are passed through. That is why the process is known as shearing, because of you literary shear the material into smaller particles.

The solid is first fed into a compartment known as a hopper which guides the product to the gap that is between the rotor and the stator. The rotor and stator surface is covered with two metal toothed coverings which cut and shear the solid.

The rotor rotates at a speed of between 3,000 and 20,000 RPM. This, in turn, distorts the fluid or solid structure as it rubs between these two rough-edged surfaces. The resultant product is then passed through to the discharge area. The drain pipe then removes the final product from the colloidal mill. If the final product has not been sheared to the desired size, it can be re-circulated back to the machine for further shearing.

Working of the Colloidal Mill :
The product to be shared is passed through the inlet which is on top of the mill known as a hopper. It is then passed through to the narrow gap between the rotor and stator. The rugged edges shear the material into the tiniest particles depending on the rotation speed. This mill uses a hydraulic system to shear the material into the final product.

It mainly works on the material that will be suspended on the liquid or emulsion. As you continue to add the heavier liquid, the suspension floats to the narrow gap and the shearing process continues. As the process continues, the two viscous elements continue to mix. There are models where both the stator and rotor rotate together and there are other models where only the rotor rotates and the stator remains still.

This mechanism is used for various purposes in the pharmaceutical field like dispersing of solid particles in an emulsion, emulsification, milling, homogenization, and improving the stability of emulsions.

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Operational Improvements for Agitated Nutsche Filter Dryers : THE BOMBAY ENGINEERING WORKS.

Agitated Nutsche filter Dryers (ANFD's) are widely used in the paint, pharmaceutical, chemical and R&D laboratory industries for the filtration and drying of active pharmaceutical ingredients (API) and chemical compounds. Plant managers understand that ANFD's offer a huge production efficiency benefits in that the filtration and dryer occurs in the same sealed unit, reducing media transfer losses and improving finished product quality.

During the ANFD filtration process, filtration occurs under vacuum or pressure in a closed vessel. After filtration, the processed media is dried into a cake substance. This operation has thus won favour by modern plant engineers as safety requirements and environmental concerns of solvent evaporation are addressed by the single unit.

A typical Standard Group ANFD consists of a dished vessel with a perforated filter plate/trolley which is typically mounted at the bottom of the vessel. The entire vessel is kept at the desired temperature by using a heating jacket, jacketed bottom dish and/or a stirrer (blade and shaft) through which heat transfer media can flow. Clearly, the vessel is made completely leak-proof for vacuum or pressurized service and typically complies with international pressure equipment directives/regulations.

During operation, the multipurpose Standard ANFD agitator performs a number of 3-axis operations with movement in axes both parallel and perpendicular to the shaft and importantly slurry contents can be kept fluidized until most of the mother liquor is filtered out. Repetitive washing, filtering and cake processing is conducted by a variety of reslurrying and vacuum techniques until the desired uniform cake consistency is created. This cake is then discharged by lowering the agitator and rotating it in such a manner that it brings the cake towards the vessel discharge port.

Unfortunately, all known ANFD designs to date suffer, to some degree, from residue cake left in the vessel and/or on the filter plate/assembly. After the ANFD paddles discharge the bulk of the cake through the discharge orifice, a small layer of cake (around 10-15mm thick) is left in on the filter, given the filter is positioned beneath the paddle, and is thus this cake is scrapped/wasted. For expensive pharmaceutical products this waste is very costly. Not only is this issue a commercial problem for the plant, it is invariably a quality issue as left over cake creates cross contamination risk/potential for the next batch, and a safety issue as operators are potentially exposed to dangerous substances.

ANFD Advantages :
Schematics Agitated Nutsche filter Dryer (ANFD) offers significant plant advantages including;
• Closed loop system - Vacuum or pressure filtration possible.
• Reduced contamination - Inert gas atmosphere can be maintained between filtration, drying and discharge.
• Integral Isolator - Minimal contamination of the cake during scraping and removal operations.
• Very high solvent recovery.
• Considerable manpower savings, including reduced work-related illnesses/lost days.
• Environmental benefits - Solvents are contained in a closed system so no toxic vapours are exhausted to the atmosphere.
• Optimised safety - Personal safety is maintained throughout the process from ANFD loading to cake discharge and cleaning/wash down
• Optimised cake quality - Heat transfer surfaces can be provided to maintain filtration temperature

ANFD Isolator Advantages :
Schematics Agitated Nutsche filter Dryer (ANFD) offers significant plant advantages including;
• Closed loop system - Vacuum or pressure filtration possible.
• Reduced contamination - Inert gas atmosphere can be maintained between filtration, drying and discharge.
• Integral Isolator - Minimal contamination of the cake during scraping and removal operations.
• Very high solvent recovery.
• Considerable manpower savings, including reduced work-related illnesses/lost days.
• Environmental benefits - Solvents are contained in a closed system so no toxic vapours are exhausted to the atmosphere.
• Optimised safety - Personal safety is maintained throughout the process from ANFD loading to cake discharge and cleaning/wash down
• Optimised cake quality - Heat transfer surfaces can be provided to maintain filtration temperature

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The Mass Mixer mainly designed for uniformly mixing of dry as well as wet material. The mass mixer takes crucial role in Pharmaceuticals, Agro Chemicals & Chemicals, Food, Herbals, etc. we offer mass mixer to perform smooth operations, of course, our machines specially designed with the self-adjusting sealing arrangement that also ensures the restriction of black particles enters the mixing drum.

You can choose mass mixer based on your needs because this device is available in different sizes. This mixer is also dealing with difficult or sticky ingredients. We also offer two-speed machine at the personable rate.

Application & Process :
The Mass Mixer is designed for uniformly mixing of dry and wet material and especially suitable for powder of Pharmaceuticals, Food, Herbals, Agro Chemicals & Chemicals.

Salient Features :
• Design is cGMP - Current Good Manufacturing Practices compliance.
• All contact parts AISI 316 & non-contact parts AISI 304.
• Uniform Mixing with paddle blade stirrer.
• Self-adjusting sealing arrangement to avoid entire black particles.
• Tilting device for easy unloading and cleaning.
• The interlocked acrylic covers of product container, enclosed drive & Overloads relay protection.
Construction :
Mass Mixer is constructed with a mixing drum covered with a see-through cover, mixing paddle arrangement and sealing arrangement. All these parts are mounted on sturdy frame which also carries motor, gear box, starter and tilting arrangement.

Safety Arraignment :
The see-through cover is interlocked. The mechanism does not let the machine start until the cover is properly closed.
Tilting Mechanism :
In order to unload the material easily, a tilting mechanism (hand wheel) is fitted in the machine. By rotating the hand wheel, mixing drum is tilted and unloaded the mixed material.

Maintenance :
Our Mass Mixer machines are designed with easy to clean and maintain features. Moving joints / parts have points to lubricate easily.

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The vacuum tray dryer is equipment used in the drying of the heat sensitive and hygroscopic materials.

DESCRIPTION :
Vacuum dryer is a modified form of the vacuum still. The vacuum dryer which is in common use in the pharmaceutical industry is called vacuum oven. It consists of a jacketed vessel made of materials which can withstand vacuum with in the oven and steam pressure in the jacket.

The oven can be closed by a door that can be lacked tightly to provide an air tight seal. The oven is connected to a vacuum pump through a condenser and a receiver. At the pressure of about 0.03 to 0.06 bars vacuum oven is operated generally.
At this pressure water boils at 25 -35 degree centigrade. In the pharmaceutical industry an oven of the size of about 1.5 m cubes having 20 shelves are commonly used.

Now days the vacuum ovens with a number of small compartments with small doors are available rather than one big compartments with a heavy door.

PRINCIPLE :
In vacuum dryer materials is dried by the principle or applications of vacuum. The water boils at a lower temperature when the pressure is lowered by creating the vacuum. So evaporation of water takes place faster.

CONSTRUCTION :
The construction of the vacuum dryer is made of with stand high vacuum pressure with cast iron heavy jacketed vessel which with stand the steam pressure in the jacket. It has enclosed space and divided in to 20 hollows shelves portions which are part of the jacket.

These shelves provide conduction of heat due to larger surface area about 45 to 50 m square provided by shelves and metal trays are placed over the shelves for keeping the materials. The oven door is locked tightly to give an air tight seal and is connected to a vacuum pump by placing condenser.

WORKING :
• The trays which are present in the dryer are used to dry the materials which are placed on the shelves and the pressure is decreased up to 30 to 60 kps by vacuum pump.
• Door is closed firmly and steam is passed through the space of jacket and shelves. So that the heat transfer takes place by the mechanism of conduction.
• Be vacuum evaporation the water is taken out from the material at 25 - 30 @c.
• Water vapour passes in to the condenser and after drying vacuum line is disconnected then the materials are collected from the trays.

PHARMACEUTICAL APPLICATIONS :
• Vacuum dryer can be used for the drying of the following
• Heat sensitive materials, Dusty materials and hygroscopic materials, toxic materials can be dried in this vacuum dyer.
• Feed materials containing the solvents are also dried by this vacuum dryer. The solvent material can be recovered by the condensation process.
• Drugs which are required as porous end products.
• Friable dry extracts can be obtained through this drying process.

ADVANTAGES :
• Handling of the materials is easy in this drying because of tray arrangement inside the dryer.
• It is easy for switching over to the next materials.
• Hollow shelves which are electrically heated can be used.
• It provides large surface area. So the heat can be easily transfer throughout the body of the dryer and fast drying action takes place.
• Hot water can be supplied throughout the dryer which helps in drying process at the desired temperature.

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The Bombay Engineering Works
We are the one of the leading manufacturers of high quality Ointment Manufacturing Plant of the related market. Our products are made employing high grade basic material & components and contemporary technology by our professionals in compliance with the International quality standards. These plants are ideal for making ointment, creams and such emulsified products. They consume moderate energy and function in a very time-saving manner. These machines can be installed easily and require minimal maintenance cost. They are resistant to corrosion wear & tear as well as abrasion. These are available in different models and specifications.

Fully automatic Ointment, Cream, Tooth Paste, Gel manufacturing plant consisting of -
• Pre-determined water phase vessel.
• Pre-determined oil, wax, and petroleum jelly phase vessel.
• Vacuum Homogenizer Mixer vessel.
• Vacuum Pump
• Storage vessel
• Interconnecting pipeline.
• Transfer Pumps (Bump Pump, Lobe Pump & Metering pumps)
• Integrated automatic control panel.
• Working Platform
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Working and principle of Rapid Mixer Granulator (RMG) - The Bombay Engineering Works

Rapid Mixer Granulator is a multi-purpose processor equally suitable for high speed dispersion of dry powders, aqueous or solvent granulation, and effervescent products and melts palletisation.

Wet granulation is a common step in the manufacture of many solid dosage pharmaceuticals. Wet granulation can be accomplished in a mixer granulator. A mechanical impeller moves the powder while a liquid binder is applied onto a moving powder bed. Addition of the liquid binder starts the formation of granules. The granulator also has a chopper.
Impeller and chopper are mainly responsible for wet granulation in the rapid mixer granulator.

Rapid Mixer Granulator is designed to achieve excellent mixing and consistent granules at lower operating cost along with higher productivity. Better mixing and closed control of granule size leads to faster tableting speeds with improved quality and least rejections.

The granulation is conventionally performed in the following process steps :
• Mixing of dry material at high impeller and chopper speeds for a few minutes.
• Addition of liquid binder by pouring it on to the powder, while both the impeller and chopper are running at a low speed.
• Wet massing with both agitators running at high speed.

1) Impellers :
Impellers are fixed at the bottom of dome shaped stainless steel bowl. It has fully length and two half-length blades. Impellers are designed such a way that small blade lift the material and full length blades push the material to mix well. These impellers break up the wet mass into small pieces and granules.

2) Chopper :
These are specially designed small blades located at the bottom of the dome. The primary function of chopper is to cuts the lumps into smaller fragments those are mixed equally by impeller and aids the bowl or sprayed onto the powder to achieve a more homogeneous liquid distribution. It rotates at high speed (1440/2880) RPM to give easy and uniform granulation. The speed of chopper is responsible for the size of granule. Chopper does not have any significant effect on the granule size when impeller speed is high (above 200 RPM).

3) Discharge Port :
The discharge port is mounted horizontally into the dome with vertical downward opening. Granules are unloaded in the container through the discharge port. Opening of discharge port is operated by pneumatic cylinder (compressed air cylinder) that requires 3-5 kg/cm2 pressure of compress air.

4) Working Principle :
• The Rapid Mixer Granulator is mixing unit with a bottom entry agitator ad side mounted chopper for granulation. It is used for dry blending, wet mixing, preparation of dough and granulation, i.e. cutting of the wet mass into small size granules. It works on the basic principle of agitation of the contents of the bowl at moderate speed and then running a specially profiled cutter blade at high speeds into the wet mass.
• Dry mixing takes about 3-5 minutes to mix the ingredients; wet mixing takes 5-10 minutes to make the wet mass of material while the granulation process takes 5-10 minute to 0.5 mm to 1.5 mm sized granules.
• Mixing time consumed in processing is depends upon the ingredients quantity and their particle size.

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Advantages of Fluid Bed Dryer in Pharmaceutical Industry -
THE BOMBAY ENGINEERING WORKS

Fluid bed dryer plays an integral role in the pharmaceutical industry. This is due to the many advantages that it offers over the conventional drying techniques.

So far, a number fluidized bed drying studies have established that it is the most reliable and dependable technique in the pharmaceutical industry.

With this information, you can comfortably choose the right pharmaceutical fluid bed dryer.

Advantages of Fluid Bed Dryer :
The available fluidized bed dryers offer a wide range of benefits depending on their unique design.

Below are the main advantages of fluidized bed dryers in the pharmaceutical industry :

1. Fluidized Bed Dryers Guarantee Fast and Homogeneous Drying
• The hot gas/air flows into the system with a velocity greater than the setting velocity of particles. This causes the particles to be suspended in the hot air or gas.
• In this fluidized state, the particle you intend to dry is actually in direct contact with the hot gas or air. Therefore, drying can be done within 10 to 40 minutes.
• Furthermore, the uniform drying is due to the fact that every particle of the solid is surrounded by hot air or gas.
• Whether you opt for a vertical or horizontal fluidized dryer, the working principle will still remain the same.

2. Fluid Bed Dryer is Suitable for Heat Sensitive Products
• Some powders and granules degrade or lose essential properties when subjected to extreme heat or temperatures.
• This makes the conventional drying systems unsuitable for such products.
• The modern fluidized bed designs have sensitive and effective sensors that monitor all essential parameters during material drying process.
• Even with the high rate of mass and heat transfer, you can still control the basic parameters that affect quality of the final product.
Fluid Bed Dryer Control Panel :
• With this control panel, you can easily monitor the temperature and air flow settings.
• That is, with the modern control system, you can adjust all parameters of the inlet air flow.

3. Fluidized Bed Ensures Efficiency in Material Drying
• The fluid bed dryer working principle is such that the particles are dried individually as opposed to the entire bed. Remember, the hot air or gas surrounds all particles and this ensures efficiency in the material drying process.
• Hot air or gas reaches every surface of the particles
• This guarantees 99.9% efficiency in the drying process while saving thermal heat.
• Normally, you’ll find that the thermal efficiency of fluid dryers is 3 times greater than those of other conventional drying systems.

4. Handling Fluidized Bed Dryer is Easy and Less Labor Intensive
• A number of fluid bed dryer designs are such that you can conveniently relocate them from one point to another. This makes handling these machines easy and less labor intensive.
• Furthermore, there are those that have wheels, making them portable material processing equipment.
A Fluid Bed Dryer with Wheels :
• This makes fluid bed dryer a perfect choice for most laboratory and R & D applications.

5. Fluid Bed Dryer Designs Come in a Wide Range of Capacities and Sizes
• Whether you’re in pharmaceutical, laboratory or R&D facility; there is that fluidized dryer design that will suit your unique application requirements. For instance, we have a wide range of fluid bed dryer equipment optimized for different applications.

6. Fluid Bed Dryer has Low Maintenance Cost hence, Reduces Downtime
• This is quite clear from the modular and cGMP compliant designs of our fluid bed dryers for pharmaceutical machines. The equipment is made from high quality stainless steel.
• Ideally, you don’t have to worry about product contamination, dust pollution, rust or tedious cleaning process.
• Furthermore, with the modular design, you can easily replace or modify this machine to suit your unique applications.
• NOTE: In case you have to modify our machines, kindly contact our technical team. Remember, hiring untrained personnel will make your warranty invalid.

7. No Hot Spots on the Final Products
• The hot spot is a common phenomenon in most drying equipment. This is because the products are in direct contact with the drying surface.
Fluid Bed Material Processing Chamber :
• All materials are suspended within the material drying chamber.
• Additionally, you can choose the right capacity of the fluid dryer where there is an excellent mixing of both the particles and air.
• Remember, in other drying applications, you cannot use high temperatures since this may cause damage to the product.
• However, for the case of fluid bed dryer, you can use high drying temperature.
• Again, due to the unique fluid bed dryer working principle; you can use this machine to dry thermolabile products. This is one of the main reasons why fluidization is common in most pharmaceutical industries.

8. Fluid Bed Dryer Is Suitable for both Continuous & Batch Material Processing
• Do you need a drying machine for both batch and continuous material processing?
• Well, I can recommend a fluidized bed dryer since it is a machine that can handle both processes without necessarily doing expensive adjustments or modifications.

Apart from these 8 advantages of fluid bed dryer, other includes :
• No risk of soluble substances migrating
• Reduced dust pollution
• Small size with high production capacity
• High rates of moisture removal

Even though a fluidized bed dryer may offer all these advantages; it may not be suitable for all pharmaceutical applications. It is for this reason that we may advise you to consider other alternatives.

Besides, even when you adopt fluid bed dryer, there are certain challenges that you’ll have to deal with.

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Augur Type Powder Filling Machines :

DESCRIPTION :
In the powder filling and auger filler pharmaceutical machine, the incoming dry bottle (sterilized and siliconized) are fed through the infeed Turn Table with suitably guided on the moving Delran flat conveyor belt at the required speed for feeding. Filling head is mounted on machine top plate. When bottle reaches to the filling station, it will be hold by the pneumatic bottle holder.

Immediately it will be sensed by the bottle sensor as soon as it gets the signals from sensor magnetic clutch starts to rotate which is mounted on auger shaft. It will fill the desired amount of powder to the bottle through auger, where rotation time is previously saved in PLC control. After filling of bottle pneumatic piston goes back and releases the bottle to move on conveyor. The main advantage of this pharmaceutical machinery is Pneumatic bottle holding system is directly connected with Auger rotation, so till bottle get filled with powder as per set value, pneumatic system will not going to release the bottle.

SALIENT FEATURES :
• Automatic Powder Filling Machines models Single head / Twin head are ideal for filling powder/granules into bottles/containers of any size and shape.
• Powder Filling Machine is ideal for dry powder, granules and dry syrup filling.
• High accuracy of powder filling system is achieved due to accurate design of Auger Screw, very sophisticated clutch brake and microprocessor control system.
• Powder filling machines come in a wide variety of sizes, shapes, filling principles and degrees of technical sophistication in response to the ever-widening diversity of powder filling applications.
• Easy to maintain and simple to operate.
• Specially designed Augurs for different types of Powder / Granules.
• An unscramble streamlines easy and trouble free feeding of the containers.
• No Container - No fill attachment.
• Quick changeover from one size to another.
• Easy and accurate adjustments of fill quantities.
• All parts coming in contact with the products are made out of stainless steel.
• Powder Filling Machine can be linked with seaming machine to have a complete automatic line.
• Infinite variable speed drive for output control can be provided if required.

AVAILABLE CAPACITIES : 20 to 50 bottles per minute depend on powder bulk density & neck diameter of container and weight to be filled.

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