About autoclave steam sterilizer machine

Autoclave Steam Sterilizer

Autoclave Steam Sterilizer


An essential prerequisite for the safety of a drug or medicine is sterility. The design of pharmaceutical autoclave steam sterilizers is consistent with the most current recommendations and guidelines, cGMP, GAMP, and FDA, to assist customers in complying with the production process’s stringent requirements. We offer a wide range of steam sterilizer autoclave solutions featuring multiple sterilization methods and single or double door sterilizers with a sufficient volume of a few hundred liters to large-scale systems with magnitudes of up to 60 m3.

Autoclaves is also known as steam sterilizers and are typically used for healthcare or industrial applications. An autoclave is a machine that uses steam under pressure to kill harmful bacteria, viruses, fungi, and spores on items that are placed inside a pressure vessel. The items are heated to an appropriate sterilization temperature for a given amount of time. The steam in the steam efficiently transfers heat to the items to destroy the bacteria and spores’ protein structure.
In healthcare, the term “autoclave” is typically used as the nomenclature to describe a Steam Sterilizer. ANSI/AAMI4, which provides standards and guidelines for the processing of medical devices.
Working of Autoclave Steam Sterilizer
Autoclaves are commonly used in healthcare settings to sterilize medical devices. The items to be sterilized are placed inside a pressure vessel, commonly referred to as the chamber. Three factors are critical to ensuring successful steam sterilization in an autoclave: time, temperature, and steam quality.

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Sterilizers are ideal for Hospitals, Research Laboratory, and other Pharmaceutical Industry. They are designed for the safe & efficient sterilization of various items such as Ampoules & Vials, Rubber goods, empty flasks, instruments & utensils, Fabrics wrapped or unwrapped, etc.


The Chamber is constructed of heavy-duty stainless steel 316 to withstand the pressure of 2.2 Kg/cm2 corresponding to a temperature of 1340 C and also to withstand a vacuum of 650-700 mm (26″/28″) of Hg. in Chamber.

Two rails are provided in the chamber bottom for easy loading & unloading of the Carriage material.


The Sterilizer helps supply with a single door or double doors made of 304/316 S .S. The doors have automatic sliding-type arrangements OR Manual Hinge type doors.

The doors will have a unique arrangement to open them manually in case of power failure.

The door Gasket will be of Silicon Rubber.

Generally, there are three phases to the autoclave process:

1] Conditioning Phase (C): Air inhibits sterilization and must be removed from the chamber during the first phase of the sterilization cycle, known as conditioning. In dynamic air removal-type steam sterilizers, the air can be removed from the chamber using a vacuum system. It can also be removed without a vacuum system using a series of steam flushes and pressure pulses. Gravity-type sterilizers use steam to displace the air in the chamber and force them down the sterilizer drain.

2] Exposure Phase (S): After the air is removed, the sterilizer drain closes, and steam is continuously admitted into the chamber, rapidly increasing the pressure and temperature inside to a predetermined level. The cycle enters the exposure phase, and items are held at the sterilization temperature for a fixed amount of time required to sterilize them.

3] Exhaust Phase (E): During the final phase of the cycle, exhaust, the sterilizer drain is opened, and steam is removed, depressurizing the vessel and allowing the items in the load to dry.

Quality steam is vital to a successful autoclave sterilization process. The steam used for sterilization should be composed of 97% steam (vapor) and 3% moisture (liquid water). This ratio is recommended for the most efficient heat transfer. When the steam moisture content is less than 3%, the steam is described as superheated (or dry). Superheated steam is too dry for efficient heat transfer and is ineffective for steam sterilization.

The temperature inside an Autoclave Steam Sterilizer

Commonly recommended temperatures for steam sterilization are 250° F (121° C), 270°F (132°C) or 275°F (135° C). To kill any microorganisms present, the sterilized items must be exposed to these temperatures for the minimum time recommended by the manufacturer of the device being processed.


A) The Special provision prevents the operator from opening the door in the following events:-

a) When the Chamber is under pressure

b) When one door is open, the other cannot be opened (for Sterilizer with 2 Doors).

c) Vacuum Breaker.

d) Heavy-duty safety valves.


* Plug Screen in the Chamber (in front)

* A Thermostatic Steam Trap/Air Vent

* S.S Baffle Plate

* Temperature and Pressure / Vacuum indicator (gauges)

* The piping is of stainless steel 304/316.


The Sterilizer is operated by steam supplied from the central boiler or by an inbuilt electric steam generator.

Steam Generator :

We can supply Autoclave with a 304/316 S. S. steam generator operable on electricity. It has safety features such as low water cut off, pressure control, etc.


This system helps offer effective air removal from the Autoclave chamber. It consists of an efficient water-ring type vacuum pump, condenser, etc.


The control unit is based on advanced PLC or Microprocessor technology. This unit control different sterilization cycles with the help of inbuilt different program combinations. We provide control with a manual operation facility.



We can supply an Autoclave with stainless steel removable shelves/trays or a loading carriage & trolleys.

Carriage & Trolley :

We make the loading carriage out of stainless steel 304/316. And it has adjustable shelves to positioned according to the Height of the goods. It also slides easily from the Chamber to the trolley.

We make trolley out of S.S.l. M.S. and its base have four heavy-duty casters.


For liquids in bottles and PVC pouches with air and water spray after the sterilization period. BLUEWATER LEAK DETECTION SYSTEM :

To detect defective Ampoules: pump preheated Blue Water into the autoclave chamber, which will penetrate the defective ampoule for easy detection.


It can be manufactured to comply with any other international standards.

AVAILABLE CAPACITIES: 50 Ltrs to 5000 Ltrs.


Model HA – 78L HA – 135L HA – 152L HA – 162L HA – 240L
Internal Tank Capacity 78 Liters 135 Liters 152 Liters 162 Liters 240 Liters
Design Rectangular & Cylindrical Type
Working Pressure Variable 5 to 30 PSI
Working Temperature 121°C (up graded up to 135°C)
Internal Chamber Corrosion Resistant Stainless Steel
External Chamber Corrosion Resistant 304 Grade Stainless Steel, Painted
Door Single or Double Doors w/ automatic pressure locking
Insulation Glass wool Fiber
Sterilization Period 20 to 25 Minutes
Steam Exhaust 5 to 7 Minutes
Boiler With ISI marked water immersion type industrial heating elements
Pressure stat,
Safety Valve For excess pressure inside jacket and steam generator
Mechanical Time w/ Alarm Regulates sterilization time and activates buzzer when sterilization cycle completes
Standard Accessories – SS304 Sterilizing tray x 1pc
– Water level glass tube x 2pcs
– Heating element x 1pc
– Silicone door seal x 1pc
Optional Accessories – PLC operation
– Vacuum drying
– Printer
– Auto add water
– Door interlock
– Automatic Pressure control switch
– water cut-off
– Temperature indicator
– Caster wheels
Power Supply 220 Volts / 440 Volts




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